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Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study

BACKGROUND: The occurrence of cognitive dysfunctions and psychological symptoms, as well as their mutual relationships, in migraine patients are still debated. The aim of the study was to characterize the cognitive profile and psychological symptoms (i.e. depression, anxiety and apathy) in drug-naïv...

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Autores principales: Santangelo, Gabriella, Russo, Antonio, Trojano, Luigi, Falco, Fabrizia, Marcuccio, Laura, Siciliano, Mattia, Conte, Francesca, Garramone, Federica, Tessitore, Alessandro, Tedeschi, Gioacchino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002274/
https://www.ncbi.nlm.nih.gov/pubmed/27568039
http://dx.doi.org/10.1186/s10194-016-0667-0
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author Santangelo, Gabriella
Russo, Antonio
Trojano, Luigi
Falco, Fabrizia
Marcuccio, Laura
Siciliano, Mattia
Conte, Francesca
Garramone, Federica
Tessitore, Alessandro
Tedeschi, Gioacchino
author_facet Santangelo, Gabriella
Russo, Antonio
Trojano, Luigi
Falco, Fabrizia
Marcuccio, Laura
Siciliano, Mattia
Conte, Francesca
Garramone, Federica
Tessitore, Alessandro
Tedeschi, Gioacchino
author_sort Santangelo, Gabriella
collection PubMed
description BACKGROUND: The occurrence of cognitive dysfunctions and psychological symptoms, as well as their mutual relationships, in migraine patients are still debated. The aim of the study was to characterize the cognitive profile and psychological symptoms (i.e. depression, anxiety and apathy) in drug-naïve migraine without aura (MwoA) patients. METHODS: Seventy-two consecutive MwoA patients, referred to the Italian University Headache Clinic and 72 healthy subjects (HCs) were enrolled. Patients, during an attack-free period, and HCs completed Montreal Cognitive Assessment (MoCA), Beck Depression Inventory-II (BDI-II), Self-version of Apathy Evaluation Scale (AES-S) and State and Trait Anxiety Inventory (STAI-Y-1 and 2). Clinical parameters of disease severity (i.e. disease duration, migraine attacks per month, mean pain intensity during migraine attacks, migraine disability and impact on daily life) were recorded. RESULTS: Although performance of MwoA patients on MoCA was above Italian cut-off threshold (<15.5) suggesting presence of cognitive impairment, MwoA patients achieved significantly lower scores than HCs on total MoCA scale (22.3 ± 2.7 versus 25.4 ± 2.3) and on its attention (4.9 ± 1.1 versus 5.6 ± 0.7), memory (1.8 ± 1.4 versus 3.1 ± 1.3), visuospatial (3.2 ± 0.9 versus 3.6 ± 0.6) and executive subscales (2.6 ± 1.1 versus 3.1 ± 0.8). In addition, we observed significant correlations between MoCA executive domain subscore and the attack-related disability score (MIDAS). As for behavioral profile, the percentage of depressive symptoms (4.2 %), high state and trait anxiety (13.9 and 9.7 %, respectively), and apathy (11.1 %) in MwoA patients were similar to that of HCs. No significant associations of behavioural symptoms with cognitive performance and clinical parameters were found. CONCLUSIONS: Drug-naïve MwoA patients are characterized by subtle cognitive dysfunctions and low percentage of behavioural symptoms. The results support the importance of searching for subclinical cognitive disturbances in patients with MwoA, who deserve to be followed-up to verify whether they develop clinically relevant disorders over time.
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spelling pubmed-50022742016-09-13 Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study Santangelo, Gabriella Russo, Antonio Trojano, Luigi Falco, Fabrizia Marcuccio, Laura Siciliano, Mattia Conte, Francesca Garramone, Federica Tessitore, Alessandro Tedeschi, Gioacchino J Headache Pain Research Article BACKGROUND: The occurrence of cognitive dysfunctions and psychological symptoms, as well as their mutual relationships, in migraine patients are still debated. The aim of the study was to characterize the cognitive profile and psychological symptoms (i.e. depression, anxiety and apathy) in drug-naïve migraine without aura (MwoA) patients. METHODS: Seventy-two consecutive MwoA patients, referred to the Italian University Headache Clinic and 72 healthy subjects (HCs) were enrolled. Patients, during an attack-free period, and HCs completed Montreal Cognitive Assessment (MoCA), Beck Depression Inventory-II (BDI-II), Self-version of Apathy Evaluation Scale (AES-S) and State and Trait Anxiety Inventory (STAI-Y-1 and 2). Clinical parameters of disease severity (i.e. disease duration, migraine attacks per month, mean pain intensity during migraine attacks, migraine disability and impact on daily life) were recorded. RESULTS: Although performance of MwoA patients on MoCA was above Italian cut-off threshold (<15.5) suggesting presence of cognitive impairment, MwoA patients achieved significantly lower scores than HCs on total MoCA scale (22.3 ± 2.7 versus 25.4 ± 2.3) and on its attention (4.9 ± 1.1 versus 5.6 ± 0.7), memory (1.8 ± 1.4 versus 3.1 ± 1.3), visuospatial (3.2 ± 0.9 versus 3.6 ± 0.6) and executive subscales (2.6 ± 1.1 versus 3.1 ± 0.8). In addition, we observed significant correlations between MoCA executive domain subscore and the attack-related disability score (MIDAS). As for behavioral profile, the percentage of depressive symptoms (4.2 %), high state and trait anxiety (13.9 and 9.7 %, respectively), and apathy (11.1 %) in MwoA patients were similar to that of HCs. No significant associations of behavioural symptoms with cognitive performance and clinical parameters were found. CONCLUSIONS: Drug-naïve MwoA patients are characterized by subtle cognitive dysfunctions and low percentage of behavioural symptoms. The results support the importance of searching for subclinical cognitive disturbances in patients with MwoA, who deserve to be followed-up to verify whether they develop clinically relevant disorders over time. Springer Milan 2016-08-27 /pmc/articles/PMC5002274/ /pubmed/27568039 http://dx.doi.org/10.1186/s10194-016-0667-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Santangelo, Gabriella
Russo, Antonio
Trojano, Luigi
Falco, Fabrizia
Marcuccio, Laura
Siciliano, Mattia
Conte, Francesca
Garramone, Federica
Tessitore, Alessandro
Tedeschi, Gioacchino
Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study
title Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study
title_full Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study
title_fullStr Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study
title_full_unstemmed Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study
title_short Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study
title_sort cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002274/
https://www.ncbi.nlm.nih.gov/pubmed/27568039
http://dx.doi.org/10.1186/s10194-016-0667-0
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