Hyperinsulinemia augments endothelin‐1 protein expression and impairs vasodilation of human skeletal muscle arterioles

Hyperinsulinemia is a hallmark of insulin resistance‐associated metabolic disorders. Under physiological conditions, insulin maintains a balance between nitric oxide (NO) and, the potent vasoconstrictor, endothelin‐1 (ET‐1). We tested the hypothesis that acute hyperinsulinemia will preferentially au...

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Detalles Bibliográficos
Autores principales: Mahmoud, Abeer M., Szczurek, Mary R., Blackburn, Brian K., Mey, Jacob T., Chen, Zhenlong, Robinson, Austin T., Bian, Jing‐Tan, Unterman, Terry G., Minshall, Richard D., Brown, Michael D., Kirwan, John P., Phillips, Shane A., Haus, Jacob M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002909/
https://www.ncbi.nlm.nih.gov/pubmed/27796268
http://dx.doi.org/10.14814/phy2.12895

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