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Exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report

Cystic fibrosis (CF) is a genetic condition affecting the respiratory and gastrointestinal systems, with patients experiencing problems maintaining weight, especially during rapid growth periods such as puberty. The aim of this case report was to monitor the effect of gastrostomy insertion and imple...

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Autores principales: Tomlinson, Owen W., Barker, Alan R., Oades, Patrick J., Williams, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002912/
https://www.ncbi.nlm.nih.gov/pubmed/27796267
http://dx.doi.org/10.14814/phy2.12904
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author Tomlinson, Owen W.
Barker, Alan R.
Oades, Patrick J.
Williams, Craig A.
author_facet Tomlinson, Owen W.
Barker, Alan R.
Oades, Patrick J.
Williams, Craig A.
author_sort Tomlinson, Owen W.
collection PubMed
description Cystic fibrosis (CF) is a genetic condition affecting the respiratory and gastrointestinal systems, with patients experiencing problems maintaining weight, especially during rapid growth periods such as puberty. The aim of this case report was to monitor the effect of gastrostomy insertion and implementation of overnight supplemental feeding upon clinical outcomes, including body mass index (BMI), lung function (FEV (1)), and exercise‐related variables (maximal oxygen uptake [VO (2max)] and ventilatory efficiency [V(E)/VO (2)]) in an 11‐year‐old female with CF. Combined incremental and supramaximal exercise testing to exhaustion was performed at four time points: 3 months prior to the procedure (T1), 2 days prior to (T2), 4 months (T3), and 1 year following the procedure (T4). Improvements following gastrostomy insertion were observed at the 1 year follow‐up with regards to BMI (+20%); whereas absolute VO (2max) remained stable and lung function fluctuated throughout the period of observation. Declines in function with regards to body weight relative VO (2max) (−16.3%) and oxygen uptake efficiency (+7.5%) were observed during this period. This case report is the first to consider exercise‐related clinical outcomes in assessing the effect of implementing gastrostomy feeding in CF. The varied direction and magnitude of the associations between variables shows that further investigations are required.
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spelling pubmed-50029122016-09-07 Exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report Tomlinson, Owen W. Barker, Alan R. Oades, Patrick J. Williams, Craig A. Physiol Rep Case Reports Cystic fibrosis (CF) is a genetic condition affecting the respiratory and gastrointestinal systems, with patients experiencing problems maintaining weight, especially during rapid growth periods such as puberty. The aim of this case report was to monitor the effect of gastrostomy insertion and implementation of overnight supplemental feeding upon clinical outcomes, including body mass index (BMI), lung function (FEV (1)), and exercise‐related variables (maximal oxygen uptake [VO (2max)] and ventilatory efficiency [V(E)/VO (2)]) in an 11‐year‐old female with CF. Combined incremental and supramaximal exercise testing to exhaustion was performed at four time points: 3 months prior to the procedure (T1), 2 days prior to (T2), 4 months (T3), and 1 year following the procedure (T4). Improvements following gastrostomy insertion were observed at the 1 year follow‐up with regards to BMI (+20%); whereas absolute VO (2max) remained stable and lung function fluctuated throughout the period of observation. Declines in function with regards to body weight relative VO (2max) (−16.3%) and oxygen uptake efficiency (+7.5%) were observed during this period. This case report is the first to consider exercise‐related clinical outcomes in assessing the effect of implementing gastrostomy feeding in CF. The varied direction and magnitude of the associations between variables shows that further investigations are required. John Wiley and Sons Inc. 2016-08-22 /pmc/articles/PMC5002912/ /pubmed/27796267 http://dx.doi.org/10.14814/phy2.12904 Text en © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Tomlinson, Owen W.
Barker, Alan R.
Oades, Patrick J.
Williams, Craig A.
Exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report
title Exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report
title_full Exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report
title_fullStr Exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report
title_full_unstemmed Exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report
title_short Exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report
title_sort exercise capacity following a percutaneous endoscopic gastrostomy in a young female with cystic fibrosis: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002912/
https://www.ncbi.nlm.nih.gov/pubmed/27796267
http://dx.doi.org/10.14814/phy2.12904
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