Cargando…

Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth

The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underl...

Descripción completa

Detalles Bibliográficos
Autores principales: Dismukes, Andrew R, Meyer, Vanessa J, Shirtcliff, Elizabeth A, Theall, Katherine P, Esteves, Kyle C, Drury, Stacy S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002957/
https://www.ncbi.nlm.nih.gov/pubmed/27221260
http://dx.doi.org/10.1530/EC-16-0007
_version_ 1782450594692202496
author Dismukes, Andrew R
Meyer, Vanessa J
Shirtcliff, Elizabeth A
Theall, Katherine P
Esteves, Kyle C
Drury, Stacy S
author_facet Dismukes, Andrew R
Meyer, Vanessa J
Shirtcliff, Elizabeth A
Theall, Katherine P
Esteves, Kyle C
Drury, Stacy S
author_sort Dismukes, Andrew R
collection PubMed
description The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological process that may overlap with TL. One hundred and two participants completed the Trier Social Stressor Test for children (TSST-C). TL was obtained from all youth from buccal swabs on the same day as the TSST-C. Saliva samples from 83 participants were obtained over the course of two additional days to measure waking and diurnal levels of DHEA. DHEA diurnal slope was a robust predictor of TL (B=0.516, P<0.05), while other DHEA values were not significantly associated with TL. This study is one of the first studies to examine basal, diurnal and reactivity measurements of DHEA in youth. Furthermore, this is the first study, to our knowledge, to demonstrate a positive association between DHEA, a putative anti-aging hormone, and TL, an indicator of cellular aging.
format Online
Article
Text
id pubmed-5002957
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Bioscientifica Ltd
record_format MEDLINE/PubMed
spelling pubmed-50029572016-08-30 Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth Dismukes, Andrew R Meyer, Vanessa J Shirtcliff, Elizabeth A Theall, Katherine P Esteves, Kyle C Drury, Stacy S Endocr Connect Research The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological process that may overlap with TL. One hundred and two participants completed the Trier Social Stressor Test for children (TSST-C). TL was obtained from all youth from buccal swabs on the same day as the TSST-C. Saliva samples from 83 participants were obtained over the course of two additional days to measure waking and diurnal levels of DHEA. DHEA diurnal slope was a robust predictor of TL (B=0.516, P<0.05), while other DHEA values were not significantly associated with TL. This study is one of the first studies to examine basal, diurnal and reactivity measurements of DHEA in youth. Furthermore, this is the first study, to our knowledge, to demonstrate a positive association between DHEA, a putative anti-aging hormone, and TL, an indicator of cellular aging. Bioscientifica Ltd 2016-05-01 /pmc/articles/PMC5002957/ /pubmed/27221260 http://dx.doi.org/10.1530/EC-16-0007 Text en © 2016 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Research
Dismukes, Andrew R
Meyer, Vanessa J
Shirtcliff, Elizabeth A
Theall, Katherine P
Esteves, Kyle C
Drury, Stacy S
Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_full Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_fullStr Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_full_unstemmed Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_short Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
title_sort diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002957/
https://www.ncbi.nlm.nih.gov/pubmed/27221260
http://dx.doi.org/10.1530/EC-16-0007
work_keys_str_mv AT dismukesandrewr diurnalandstressreactivedehydroepiandrosteronelevelsandtelomerelengthinyouth
AT meyervanessaj diurnalandstressreactivedehydroepiandrosteronelevelsandtelomerelengthinyouth
AT shirtcliffelizabetha diurnalandstressreactivedehydroepiandrosteronelevelsandtelomerelengthinyouth
AT theallkatherinep diurnalandstressreactivedehydroepiandrosteronelevelsandtelomerelengthinyouth
AT esteveskylec diurnalandstressreactivedehydroepiandrosteronelevelsandtelomerelengthinyouth
AT drurystacys diurnalandstressreactivedehydroepiandrosteronelevelsandtelomerelengthinyouth