Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning

Learning can lead to changes in the intrinsic excitability of neurons. However, it is unclear to what extent these changes persist and what role they play in the expression of memory. Here, we report that in vitro analogues of operant conditioning produce a long-term (24 h) increase in the excitabil...

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Autores principales: Mozzachiodi, Riccardo, Lorenzetti, Fred D., Baxter, Douglas A., Byrne, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003050/
https://www.ncbi.nlm.nih.gov/pubmed/18776897
http://dx.doi.org/10.1038/nn.2184
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author Mozzachiodi, Riccardo
Lorenzetti, Fred D.
Baxter, Douglas A.
Byrne, John H.
author_facet Mozzachiodi, Riccardo
Lorenzetti, Fred D.
Baxter, Douglas A.
Byrne, John H.
author_sort Mozzachiodi, Riccardo
collection PubMed
description Learning can lead to changes in the intrinsic excitability of neurons. However, it is unclear to what extent these changes persist and what role they play in the expression of memory. Here, we report that in vitro analogues of operant conditioning produce a long-term (24 h) increase in the excitability of an identified neuron (B51) critical for the expression of feeding in Aplysia. This increase in excitability, which is cAMP dependent, contributes to the associative modification of the feeding circuitry, providing a mechanism for long-term memory storage.
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spelling pubmed-50030502016-08-29 Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning Mozzachiodi, Riccardo Lorenzetti, Fred D. Baxter, Douglas A. Byrne, John H. Nat Neurosci Article Learning can lead to changes in the intrinsic excitability of neurons. However, it is unclear to what extent these changes persist and what role they play in the expression of memory. Here, we report that in vitro analogues of operant conditioning produce a long-term (24 h) increase in the excitability of an identified neuron (B51) critical for the expression of feeding in Aplysia. This increase in excitability, which is cAMP dependent, contributes to the associative modification of the feeding circuitry, providing a mechanism for long-term memory storage. 2008-09-07 2008-10 /pmc/articles/PMC5003050/ /pubmed/18776897 http://dx.doi.org/10.1038/nn.2184 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Mozzachiodi, Riccardo
Lorenzetti, Fred D.
Baxter, Douglas A.
Byrne, John H.
Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning
title Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning
title_full Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning
title_fullStr Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning
title_full_unstemmed Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning
title_short Changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning
title_sort changes in neuronal excitability serve as a mechanism of long-term memory for operant conditioning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003050/
https://www.ncbi.nlm.nih.gov/pubmed/18776897
http://dx.doi.org/10.1038/nn.2184
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