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Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men

Our objective was to investigate the impact of EPA versus DHA on arterial stiffness and reactivity and underlying mechanisms (with a focus on plasma oxylipins) in the postprandial state. In a three-arm crossover acute test meal trial, men (n = 26, 35–55 years) at increased CVD risk received a high-f...

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Autores principales: McManus, Seán, Tejera, Noemi, Awwad, Khader, Vauzour, David, Rigby, Neil, Fleming, Ingrid, Cassidy, Aedin, Minihane, Anne Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003154/
https://www.ncbi.nlm.nih.gov/pubmed/27170732
http://dx.doi.org/10.1194/jlr.M067801
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author McManus, Seán
Tejera, Noemi
Awwad, Khader
Vauzour, David
Rigby, Neil
Fleming, Ingrid
Cassidy, Aedin
Minihane, Anne Marie
author_facet McManus, Seán
Tejera, Noemi
Awwad, Khader
Vauzour, David
Rigby, Neil
Fleming, Ingrid
Cassidy, Aedin
Minihane, Anne Marie
author_sort McManus, Seán
collection PubMed
description Our objective was to investigate the impact of EPA versus DHA on arterial stiffness and reactivity and underlying mechanisms (with a focus on plasma oxylipins) in the postprandial state. In a three-arm crossover acute test meal trial, men (n = 26, 35–55 years) at increased CVD risk received a high-fat (42.4 g) test meal providing 4.16 g of EPA or DHA or control oil in random order. At 0 h and 4 h, blood samples were collected to quantify plasma fatty acids, long chain n-3 PUFA-derived oxylipins, nitrite and hydrogen sulfide, and serum lipids and glucose. Vascular function was assessed using blood pressure, reactive hyperemia index, pulse wave velocity, and augmentation index (AIx). The DHA-rich oil significantly reduced AIx by 13% (P = 0.047) with the decrease following EPA-rich oil intervention not reaching statistical significance. Both interventions increased EPA- and DHA-derived oxylipins in the acute postprandial state, with an (1.3-fold) increase in 19,20-dihydroxydocosapentaenoic acid evident after DHA intervention (P < 0.001). In conclusion, a single dose of DHA significantly improved postprandial arterial stiffness as assessed by AIx, which if sustained would be associated with a significant decrease in CVD risk. The observed increases in oxylipins provide a mechanistic insight into the AIx effect.
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spelling pubmed-50031542016-09-08 Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men McManus, Seán Tejera, Noemi Awwad, Khader Vauzour, David Rigby, Neil Fleming, Ingrid Cassidy, Aedin Minihane, Anne Marie J Lipid Res Patient-Oriented and Epidemiological Research Our objective was to investigate the impact of EPA versus DHA on arterial stiffness and reactivity and underlying mechanisms (with a focus on plasma oxylipins) in the postprandial state. In a three-arm crossover acute test meal trial, men (n = 26, 35–55 years) at increased CVD risk received a high-fat (42.4 g) test meal providing 4.16 g of EPA or DHA or control oil in random order. At 0 h and 4 h, blood samples were collected to quantify plasma fatty acids, long chain n-3 PUFA-derived oxylipins, nitrite and hydrogen sulfide, and serum lipids and glucose. Vascular function was assessed using blood pressure, reactive hyperemia index, pulse wave velocity, and augmentation index (AIx). The DHA-rich oil significantly reduced AIx by 13% (P = 0.047) with the decrease following EPA-rich oil intervention not reaching statistical significance. Both interventions increased EPA- and DHA-derived oxylipins in the acute postprandial state, with an (1.3-fold) increase in 19,20-dihydroxydocosapentaenoic acid evident after DHA intervention (P < 0.001). In conclusion, a single dose of DHA significantly improved postprandial arterial stiffness as assessed by AIx, which if sustained would be associated with a significant decrease in CVD risk. The observed increases in oxylipins provide a mechanistic insight into the AIx effect. The American Society for Biochemistry and Molecular Biology 2016-09 /pmc/articles/PMC5003154/ /pubmed/27170732 http://dx.doi.org/10.1194/jlr.M067801 Text en Copyright © 2016 by the American Society for Biochemistry and Molecular Biology, Inc. http://creativecommons.org/licenses/by/4.0/ Author’s Choice—Final version free via Creative Commons CC-BY license.
spellingShingle Patient-Oriented and Epidemiological Research
McManus, Seán
Tejera, Noemi
Awwad, Khader
Vauzour, David
Rigby, Neil
Fleming, Ingrid
Cassidy, Aedin
Minihane, Anne Marie
Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men
title Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men
title_full Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men
title_fullStr Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men
title_full_unstemmed Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men
title_short Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men
title_sort differential effects of epa versus dha on postprandial vascular function and the plasma oxylipin profile in men
topic Patient-Oriented and Epidemiological Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003154/
https://www.ncbi.nlm.nih.gov/pubmed/27170732
http://dx.doi.org/10.1194/jlr.M067801
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