The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer

Survival from pancreatic cancer remains poor. Conventional treatment has resulted in only marginal improvements in survival compared with survival in the previous several decades. Thus, considerable interest has emerged regarding the potential use of common pharmaceutical agents as chemopreventative...

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Detalles Bibliográficos
Autores principales: Amin, Sunil, Boffetta, Paolo, Lucas, Aimee L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003188/
https://www.ncbi.nlm.nih.gov/pubmed/27563018
http://dx.doi.org/10.5009/gnl15451
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author Amin, Sunil
Boffetta, Paolo
Lucas, Aimee L.
author_facet Amin, Sunil
Boffetta, Paolo
Lucas, Aimee L.
author_sort Amin, Sunil
collection PubMed
description Survival from pancreatic cancer remains poor. Conventional treatment has resulted in only marginal improvements in survival compared with survival in the previous several decades. Thus, considerable interest has emerged regarding the potential use of common pharmaceutical agents as chemopreventative and chemotherapeutic options. Aspirin, metformin, statins, β-blockers, and bisphosphonates have biologically plausible mechanisms to inhibit pancreatic neoplasia, whereas dipeptidyl-peptidase 4 inhibitors may promote it. Regardless, real-world epidemiological data remain inconclusive. This review examines the hypotheses, evidence, and current state of the literature for each of these medications and their potential roles in the prevention and treatment of pancreatic cancer.
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spelling pubmed-50031882016-09-09 The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer Amin, Sunil Boffetta, Paolo Lucas, Aimee L. Gut Liver Review Survival from pancreatic cancer remains poor. Conventional treatment has resulted in only marginal improvements in survival compared with survival in the previous several decades. Thus, considerable interest has emerged regarding the potential use of common pharmaceutical agents as chemopreventative and chemotherapeutic options. Aspirin, metformin, statins, β-blockers, and bisphosphonates have biologically plausible mechanisms to inhibit pancreatic neoplasia, whereas dipeptidyl-peptidase 4 inhibitors may promote it. Regardless, real-world epidemiological data remain inconclusive. This review examines the hypotheses, evidence, and current state of the literature for each of these medications and their potential roles in the prevention and treatment of pancreatic cancer. Editorial Office of Gut and Liver 2016-09 2016-09-15 /pmc/articles/PMC5003188/ /pubmed/27563018 http://dx.doi.org/10.5009/gnl15451 Text en Copyright © 2016 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Amin, Sunil
Boffetta, Paolo
Lucas, Aimee L.
The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer
title The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer
title_full The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer
title_fullStr The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer
title_full_unstemmed The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer
title_short The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer
title_sort role of common pharmaceutical agents on the prevention and treatment of pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003188/
https://www.ncbi.nlm.nih.gov/pubmed/27563018
http://dx.doi.org/10.5009/gnl15451
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