Cargando…

Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease

BACKGROUND/AIMS: Deficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by tra...

Descripción completa

Detalles Bibliográficos
Autores principales: Ko, Bong Jin, Kim, Young Seok, Kim, Sang Gyune, Park, Jung Hwan, Lee, Sae Hwan, Jeong, Soung Won, Jang, Jae Young, Kim, Hong Soo, Kim, Boo Sung, Kim, Sun Mi, Kim, Young Don, Cheon, Gab Jin, Lee, Bo Ra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003207/
https://www.ncbi.nlm.nih.gov/pubmed/27114415
http://dx.doi.org/10.5009/gnl15331
_version_ 1782450624707690496
author Ko, Bong Jin
Kim, Young Seok
Kim, Sang Gyune
Park, Jung Hwan
Lee, Sae Hwan
Jeong, Soung Won
Jang, Jae Young
Kim, Hong Soo
Kim, Boo Sung
Kim, Sun Mi
Kim, Young Don
Cheon, Gab Jin
Lee, Bo Ra
author_facet Ko, Bong Jin
Kim, Young Seok
Kim, Sang Gyune
Park, Jung Hwan
Lee, Sae Hwan
Jeong, Soung Won
Jang, Jae Young
Kim, Hong Soo
Kim, Boo Sung
Kim, Sun Mi
Kim, Young Don
Cheon, Gab Jin
Lee, Bo Ra
author_sort Ko, Bong Jin
collection PubMed
description BACKGROUND/AIMS: Deficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD. METHODS: Serum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria: patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant. RESULTS: The most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [≥9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis: 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p<0.001). CONCLUSIONS: Patients with compensated CLD exhibit a close correlation between vitamin D level and liver stiffness as assessed by TE. Vitamin D deficiency was independently associated with advanced liver fibrosis.
format Online
Article
Text
id pubmed-5003207
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Editorial Office of Gut and Liver
record_format MEDLINE/PubMed
spelling pubmed-50032072016-09-09 Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease Ko, Bong Jin Kim, Young Seok Kim, Sang Gyune Park, Jung Hwan Lee, Sae Hwan Jeong, Soung Won Jang, Jae Young Kim, Hong Soo Kim, Boo Sung Kim, Sun Mi Kim, Young Don Cheon, Gab Jin Lee, Bo Ra Gut Liver Original Article BACKGROUND/AIMS: Deficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD. METHODS: Serum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria: patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant. RESULTS: The most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [≥9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis: 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p<0.001). CONCLUSIONS: Patients with compensated CLD exhibit a close correlation between vitamin D level and liver stiffness as assessed by TE. Vitamin D deficiency was independently associated with advanced liver fibrosis. Editorial Office of Gut and Liver 2016-09 2016-04-28 /pmc/articles/PMC5003207/ /pubmed/27114415 http://dx.doi.org/10.5009/gnl15331 Text en Copyright © 2016 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ko, Bong Jin
Kim, Young Seok
Kim, Sang Gyune
Park, Jung Hwan
Lee, Sae Hwan
Jeong, Soung Won
Jang, Jae Young
Kim, Hong Soo
Kim, Boo Sung
Kim, Sun Mi
Kim, Young Don
Cheon, Gab Jin
Lee, Bo Ra
Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease
title Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease
title_full Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease
title_fullStr Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease
title_full_unstemmed Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease
title_short Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease
title_sort relationship between 25-hydroxyvitamin d levels and liver fibrosis as assessed by transient elastography in patients with chronic liver disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003207/
https://www.ncbi.nlm.nih.gov/pubmed/27114415
http://dx.doi.org/10.5009/gnl15331
work_keys_str_mv AT kobongjin relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT kimyoungseok relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT kimsanggyune relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT parkjunghwan relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT leesaehwan relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT jeongsoungwon relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT jangjaeyoung relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT kimhongsoo relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT kimboosung relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT kimsunmi relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT kimyoungdon relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT cheongabjin relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease
AT leebora relationshipbetween25hydroxyvitamindlevelsandliverfibrosisasassessedbytransientelastographyinpatientswithchronicliverdisease