A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

The endoplasmic reticulum (ER) is involved in Ca(2+) signaling and protein folding. ER Ca(2+) depletion and accumulation of unfolded proteins activate the molecular chaperone GRP78 (glucose-regulated protein 78) which in turn triggers the ER stress response (ERSR) pathway aimed to restore ER homeost...

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Detalles Bibliográficos
Autores principales: Martinez, Natalia J., Rai, Ganesha, Yasgar, Adam, Lea, Wendy A., Sun, Hongmao, Wang, Yuhong, Luci, Diane K., Yang, Shyh-Ming, Nishihara, Kana, Takeda, Shunichi, Sagor, Mohiuddin, Earnshaw, Irina, Okada, Tetsuya, Mori, Kazutoshi, Wilson, Kelli, Riggins, Gregory J., Xia, Menghang, Grimaldi, Maurizio, Jadhav, Ajit, Maloney, David J., Simeonov, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003374/
https://www.ncbi.nlm.nih.gov/pubmed/27570969
http://dx.doi.org/10.1371/journal.pone.0161486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003374/
https://www.ncbi.nlm.nih.gov/pubmed/27570969
http://dx.doi.org/10.1371/journal.pone.0161486

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