Cargando…

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel d-Amino Acid Oxidase Inhibitors

[Image: see text] A series of 2-substituted 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives were synthesized as inhibitors of d-amino acid oxidase (DAAO). Many compounds in this series were found to be potent DAAO inhibitors, with IC(50) values in the double-digit nanomolar range. The 6-hydrox...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hin, Niyada, Duvall, Bridget, Ferraris, Dana, Alt, Jesse, Thomas, Ajit G., Rais, Rana, Rojas, Camilo, Wu, Ying, Wozniak, Krystyna M., Slusher, Barbara S., Tsukamoto, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003509/ https://www.ncbi.nlm.nih.gov/pubmed/26309148 http://dx.doi.org/10.1021/acs.jmedchem.5b00482

Ejemplares similares

An Optimized Synthesis, Molecular Structure and Characterization of Benzylic Derivatives of 1,2,4-Triazin-3,5(2H,4H)-dione
por: Hwang, Long-Chih, et al.
Publicado: (2017)

2-[(Cyclohex-3-en-1-ylmethoxy)methyl]-6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione
por: El-Brollosy, Nasser R., et al.
Publicado: (2012)

Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity
por: Santra, Sougata, et al.
Publicado: (2023)

Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold
por: Tzvetkov, Nikolay T, et al.
Publicado: (2012)

Crystal Structure Analysis of 4-Oxo, 4-hydroxy- and 4-alkyl-7-bromopyrazolo[5,1-c][1,2,4]triazines
por: Ivanov, Sergey M., et al.
Publicado: (2022)

Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer
por: Hermanowicz, Justyna Magdalena, et al.
Publicado: (2021)

4-Amino-3-(4-hydroxyphenyl)-1H-1,2,4-triazol-5(4H)-one
por: Shi, Kai-Ge, et al.
Publicado: (2008)

2-Ethoxymethyl-6-ethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione
por: El-Brollosy, Nasser R., et al.
Publicado: (2012)

1,3-Dimethyl-5-methylsulfonyl-1H-pyrazolo[4,3-e][1,2,4]triazine
por: Mojzych, Mariusz, et al.
Publicado: (2010)

Strain-Promoted Reaction of 1,2,4-Triazines with Bicyclononynes
por: Horner, Katherine A, et al.
Publicado: (2015)

4-Hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-c][1,2,4]triazines: synthesis, antiviral activity, and electrochemical characteristics
por: Drokin, R. A., et al.
Publicado: (2022)

(E)-4-(2-Hydroxy-3-methoxybenzylideneamino)-6-methyl-3-sulfanylidene-3,4-dihydro-1,2,4-triazin-5(2H)-one
por: Shirinkam, Bahareh, et al.
Publicado: (2012)

5,6-Dimethyl-1,2,4-triazin-3-amine
por: Wu, Man-Hua, et al.
Publicado: (2011)

3-Methylsulfanyl-5-phenyl-1,2,4-triazine
por: Hamri, Salha, et al.
Publicado: (2014)

3-(6-Bromo-4-oxo-4H-chromen-3-yl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dione
por: al-Rashida, Mariya, et al.
Publicado: (2010)

3-(6-Fluoro-4-oxo-4H-chromen-3-yl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dione
por: al-Rashida, Mariya, et al.
Publicado: (2010)

New Heterocyclic Compounds from Oxazol-5(4H)-one and 1,2,4-Triazin-6(5H)-one Classes: Synthesis, Characterization and Toxicity Evaluation
por: Barbuceanu, Stefania-Felicia, et al.
Publicado: (2023)

1-Methyl-2-(4-methylphenyl)-4-morpholinopyridazine-3,6(1H,2H)-dione
por: Gzella, Andrzej, et al.
Publicado: (2008)

4a-Hydroxy-9-(4-hydroxyphenyl)-4,4a,5,6,9,9a-hexahydro-3H-xanthene-1,8(2H,7H)-dione
por: Wang, Liying, et al.
Publicado: (2011)

Efficient Routes to Pyrazolo[3,4-e][1,2,4]triazines and a New Ring System: [1,2,4]Triazino[5,6-d][1,2,3]triazines
por: Al-Matar, Hamad Mohamed, et al.
Publicado: (2010)

Quinazoline-2,4(1H,3H)-dione
por: Liu, Ge
Publicado: (2008)

3-Ethyl-3-hydroxy-8-methoxyquinoline-2,4(1H,3H)-dione monohydrate
por: Kafka, Stanislav, et al.
Publicado: (2012)

4-(5-Bromo-2-hydroxybenzylideneamino)-3-methyl-1H-1,2,4-triazole-5(4H)-thione
por: Wang, Min, et al.
Publicado: (2008)

4-[(2,4-Dimethylthiazol-5-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

The discovery of pyridinium 1,2,4-triazines with enhanced performance in bioconjugation reactions
por: Siegl, Sebastian J., et al.
Publicado: (2017)

Revisiting the Synthesis of Functionally Substituted 1,4-Dihydrobenzo[e][1,2,4]triazines
por: Epishina, Margarita A., et al.
Publicado: (2022)

5-Amino-3-(4H-1,2,4-triazol-4-yl)-1H-1,2,4-triazole
por: Liu, Bing, et al.
Publicado: (2012)

1,4-Dihydroxyquinoxaline-2,3(1H,4H)-dione
por: Abu-El-Halawah, Rajab, et al.
Publicado: (2008)

Synthesis, solvatochromism and crystal structure of 5-Methoxy-5,6-diphenyl-4,5-dihydro-2H −1,2,4-triazine-3-thione
por: Rezaei, Behrooz, et al.
Publicado: (2013)

4-[(2,4-Dimethyl-1,3-oxazol-5-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

3-Benzyl-7-(2,4-dichlorophenyl)-4H-1,3,4-thiadiazolo[2,3-c][1,2,4]triazin-4-one
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

2-Phenyl-7-(4-pyridylmethylamino)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5(4H)-one
por: Dolzhenko, Anton V., et al.
Publicado: (2010)

6-{5-Amino-3-tert-butyl-4-[(E)-(3-methyl-1,2,4-thiadiazol-5-yl)diazenyl]-1H-pyrazol-1-yl}-1,3,5-triazine-2,4(1H,3H)-dione–1-methylpyrrolidin-2-one–water (1/1/1)
por: Shibata, Hiroki, et al.
Publicado: (2010)

Molecular modeling studies of 1,2,4-triazine derivatives as novel h-DAAO inhibitors by 3D-QSAR, docking and dynamics simulations
por: Qian, Ping Ping, et al.
Publicado: (2018)

Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
por: Bernat, Zofia, et al.
Publicado: (2020)

4-[(2,5-Dimethyl-1,3-thiazol-4-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

5,6-Diphenyl-3-(3-pyridyl)-1,2,4-triazine
por: Jian, Fang-Fang, et al.
Publicado: (2010)

2-(5,6-Diphenyl-1,2,4-triazin-3-yl)aniline
por: Mojzych, Mariusz, et al.
Publicado: (2012)

First Synthesis of 3-Glycopyranosyl-1,2,4-Triazines and Some Cycloadditions Thereof
por: Bokor, Éva, et al.
Publicado: (2022)

Trifluoromethylated 4,5-Dihydro-1,2,4-triazin-6(1H)-ones via (3+3)-Annulation of Nitrile Imines with α-Amino Esters
por: Kowalczyk, Anna, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_l1ji8pq8e85fvhis79svj16cme