Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Autosomal dominant mutations that activate the leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson's disease. Recent work has revealed that LRRK2 directly phosphorylates a conserved threonine/serine residue in the effector-binding switch-II motif of a number of Rab GTPase proteins, i...

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Detalles Bibliográficos
Autores principales: Ito, Genta, Katsemonova, Kristina, Tonelli, Francesca, Lis, Pawel, Baptista, Marco A.S., Shpiro, Natalia, Duddy, Graham, Wilson, Steve, Ho, Philip Wing-Lok, Ho, Shu-Leong, Reith, Alastair D., Alessi, Dario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003698/
https://www.ncbi.nlm.nih.gov/pubmed/27474410
http://dx.doi.org/10.1042/BCJ20160557

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