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Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease

Key challenges faced by all cells include how to spatiotemporally organize complex biochemistry and how to respond to environmental fluctuations. The budding yeast Saccharomyces cerevisiae harnesses alternative protein folding mediated by yeast prion domains (PrDs) for rapid evolution of new traits...

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Detalles Bibliográficos
Autores principales: March, Zachary M., King, Oliver D., Shorter, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003744/
https://www.ncbi.nlm.nih.gov/pubmed/26996412
http://dx.doi.org/10.1016/j.brainres.2016.02.037