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Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s
The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken f...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004061/ https://www.ncbi.nlm.nih.gov/pubmed/27610247 http://dx.doi.org/10.1155/2016/9024173 |
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author | Patel, Apurv Dodiya, Hitesh Shelate, Pragna Shastri, Divyesh Dave, Divyang |
author_facet | Patel, Apurv Dodiya, Hitesh Shelate, Pragna Shastri, Divyesh Dave, Divyang |
author_sort | Patel, Apurv |
collection | PubMed |
description | The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken factorial design to find out the best formulation. For screening of three categories of polymers, six independent variables were chosen for Plackett-Burman design. Osmotic agent sodium chloride and microcrystalline cellulose, pore forming agent sodium lauryl sulphate and sucrose, and coating agent ethyl cellulose and cellulose acetate were chosen as independent variables. Optimization of osmotic tablets was done by Box-Behnken design by selecting three independent variables. Osmotic agent sodium chloride, pore forming agent sodium lauryl sulphate, and coating agent cellulose acetate were chosen as independent variables. The result of Plackett-Burman and Box-Behnken design and ANOVA studies revealed that osmotic agent and pore former had significant effect on the drug release up to 12 hr. The observed independent variables were found to be very close to predicted values of most satisfactory formulation which demonstrates the feasibility of the optimization procedure in successful development of porous osmotic pump tablets containing antibiotic drug/s by using sodium chloride, sodium lauryl sulphate, and cellulose acetate as key excipients. |
format | Online Article Text |
id | pubmed-5004061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-50040612016-09-08 Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s Patel, Apurv Dodiya, Hitesh Shelate, Pragna Shastri, Divyesh Dave, Divyang J Drug Deliv Research Article The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken factorial design to find out the best formulation. For screening of three categories of polymers, six independent variables were chosen for Plackett-Burman design. Osmotic agent sodium chloride and microcrystalline cellulose, pore forming agent sodium lauryl sulphate and sucrose, and coating agent ethyl cellulose and cellulose acetate were chosen as independent variables. Optimization of osmotic tablets was done by Box-Behnken design by selecting three independent variables. Osmotic agent sodium chloride, pore forming agent sodium lauryl sulphate, and coating agent cellulose acetate were chosen as independent variables. The result of Plackett-Burman and Box-Behnken design and ANOVA studies revealed that osmotic agent and pore former had significant effect on the drug release up to 12 hr. The observed independent variables were found to be very close to predicted values of most satisfactory formulation which demonstrates the feasibility of the optimization procedure in successful development of porous osmotic pump tablets containing antibiotic drug/s by using sodium chloride, sodium lauryl sulphate, and cellulose acetate as key excipients. Hindawi Publishing Corporation 2016 2016-08-16 /pmc/articles/PMC5004061/ /pubmed/27610247 http://dx.doi.org/10.1155/2016/9024173 Text en Copyright © 2016 Apurv Patel et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Patel, Apurv Dodiya, Hitesh Shelate, Pragna Shastri, Divyesh Dave, Divyang Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s |
title | Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s |
title_full | Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s |
title_fullStr | Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s |
title_full_unstemmed | Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s |
title_short | Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s |
title_sort | design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004061/ https://www.ncbi.nlm.nih.gov/pubmed/27610247 http://dx.doi.org/10.1155/2016/9024173 |
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