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Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s

The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken f...

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Autores principales: Patel, Apurv, Dodiya, Hitesh, Shelate, Pragna, Shastri, Divyesh, Dave, Divyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004061/
https://www.ncbi.nlm.nih.gov/pubmed/27610247
http://dx.doi.org/10.1155/2016/9024173
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author Patel, Apurv
Dodiya, Hitesh
Shelate, Pragna
Shastri, Divyesh
Dave, Divyang
author_facet Patel, Apurv
Dodiya, Hitesh
Shelate, Pragna
Shastri, Divyesh
Dave, Divyang
author_sort Patel, Apurv
collection PubMed
description The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken factorial design to find out the best formulation. For screening of three categories of polymers, six independent variables were chosen for Plackett-Burman design. Osmotic agent sodium chloride and microcrystalline cellulose, pore forming agent sodium lauryl sulphate and sucrose, and coating agent ethyl cellulose and cellulose acetate were chosen as independent variables. Optimization of osmotic tablets was done by Box-Behnken design by selecting three independent variables. Osmotic agent sodium chloride, pore forming agent sodium lauryl sulphate, and coating agent cellulose acetate were chosen as independent variables. The result of Plackett-Burman and Box-Behnken design and ANOVA studies revealed that osmotic agent and pore former had significant effect on the drug release up to 12 hr. The observed independent variables were found to be very close to predicted values of most satisfactory formulation which demonstrates the feasibility of the optimization procedure in successful development of porous osmotic pump tablets containing antibiotic drug/s by using sodium chloride, sodium lauryl sulphate, and cellulose acetate as key excipients.
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spelling pubmed-50040612016-09-08 Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s Patel, Apurv Dodiya, Hitesh Shelate, Pragna Shastri, Divyesh Dave, Divyang J Drug Deliv Research Article The objective of this work was design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s. Osmotic drug delivery system was chosen as controlled drug delivery system. The porous osmotic pump tablets were designed using Plackett-Burman and Box-Behnken factorial design to find out the best formulation. For screening of three categories of polymers, six independent variables were chosen for Plackett-Burman design. Osmotic agent sodium chloride and microcrystalline cellulose, pore forming agent sodium lauryl sulphate and sucrose, and coating agent ethyl cellulose and cellulose acetate were chosen as independent variables. Optimization of osmotic tablets was done by Box-Behnken design by selecting three independent variables. Osmotic agent sodium chloride, pore forming agent sodium lauryl sulphate, and coating agent cellulose acetate were chosen as independent variables. The result of Plackett-Burman and Box-Behnken design and ANOVA studies revealed that osmotic agent and pore former had significant effect on the drug release up to 12 hr. The observed independent variables were found to be very close to predicted values of most satisfactory formulation which demonstrates the feasibility of the optimization procedure in successful development of porous osmotic pump tablets containing antibiotic drug/s by using sodium chloride, sodium lauryl sulphate, and cellulose acetate as key excipients. Hindawi Publishing Corporation 2016 2016-08-16 /pmc/articles/PMC5004061/ /pubmed/27610247 http://dx.doi.org/10.1155/2016/9024173 Text en Copyright © 2016 Apurv Patel et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Patel, Apurv
Dodiya, Hitesh
Shelate, Pragna
Shastri, Divyesh
Dave, Divyang
Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s
title Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s
title_full Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s
title_fullStr Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s
title_full_unstemmed Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s
title_short Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s
title_sort design, characterization, and optimization of controlled drug delivery system containing antibiotic drug/s
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004061/
https://www.ncbi.nlm.nih.gov/pubmed/27610247
http://dx.doi.org/10.1155/2016/9024173
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