In vivo mutagenesis of miRNA gene families using a scalable multiplexed CRISPR/Cas9 nuclease system

A large number of microRNAs (miRNAs) are grouped into families derived from the same phylogenetic ancestors. miRNAs within a family often share the same physiological functions despite differences in their primary sequences, secondary structures, or chromosomal locations. Consequently, the generatio...

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Detalles Bibliográficos
Autores principales: Narayanan, Anand, Hill-Teran, Guillermina, Moro, Albertomaria, Ristori, Emma, Kasper, Dionna M., A. Roden, Christine, Lu, Jun, Nicoli, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004112/
https://www.ncbi.nlm.nih.gov/pubmed/27572667
http://dx.doi.org/10.1038/srep32386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004112/
https://www.ncbi.nlm.nih.gov/pubmed/27572667
http://dx.doi.org/10.1038/srep32386

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