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Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream

The subventricular zone (SVZ) provides a constant supply of new neurons to the olfactory bulb (OB). Different studies have investigated the role of olfactory sensory input to neural precursor cell (NPC) turnover in the SVZ but it was not addressed if a reduced demand specifically for periglomerular...

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Autores principales: Langenfurth, Anika, Gu, Song, Bautze, Verena, Zhang, Caiyi, Neumann, Julia E., Schüller, Ulrich, Stock, Kristin, Wolf, Susanne A., Maier, Anna-Maria, Mastrella, Giorgia, Pak, Andrew, Cheng, Hongwei, Kälin, Roland E., Holmbeck, Kenn, Strotmann, Jörg, Kettenmann, Helmut, Glass, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004164/
https://www.ncbi.nlm.nih.gov/pubmed/27573347
http://dx.doi.org/10.1038/srep32203
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author Langenfurth, Anika
Gu, Song
Bautze, Verena
Zhang, Caiyi
Neumann, Julia E.
Schüller, Ulrich
Stock, Kristin
Wolf, Susanne A.
Maier, Anna-Maria
Mastrella, Giorgia
Pak, Andrew
Cheng, Hongwei
Kälin, Roland E.
Holmbeck, Kenn
Strotmann, Jörg
Kettenmann, Helmut
Glass, Rainer
author_facet Langenfurth, Anika
Gu, Song
Bautze, Verena
Zhang, Caiyi
Neumann, Julia E.
Schüller, Ulrich
Stock, Kristin
Wolf, Susanne A.
Maier, Anna-Maria
Mastrella, Giorgia
Pak, Andrew
Cheng, Hongwei
Kälin, Roland E.
Holmbeck, Kenn
Strotmann, Jörg
Kettenmann, Helmut
Glass, Rainer
author_sort Langenfurth, Anika
collection PubMed
description The subventricular zone (SVZ) provides a constant supply of new neurons to the olfactory bulb (OB). Different studies have investigated the role of olfactory sensory input to neural precursor cell (NPC) turnover in the SVZ but it was not addressed if a reduced demand specifically for periglomerular neurons impacts on NPC-traits in the rostral migratory stream (RMS). We here report that membrane type-1 matrix metalloproteinase (MT1-MMP) deficient mice have reduced complexity of the nasal turbinates, decreased sensory innervation of the OB, reduced numbers of olfactory glomeruli and reduced OB-size without alterations in SVZ neurogenesis. Large parts of the RMS were fully preserved in MT1-MMP-deficient mice, but we detected an increase in cell death-levels and a decrease in SVZ-derived neuroblasts in the distal RMS, as compared to controls. BrdU-tracking experiments showed that homing of NPCs specifically to the glomerular layer was reduced in MT1-MMP-deficient mice in contrast to controls while numbers of tracked cells remained equal in other OB-layers throughout all experimental groups. Altogether, our data show the demand for olfactory interneurons in the glomerular layer modulates cell turnover in the RMS, but has no impact on subventricular neurogenesis.
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spelling pubmed-50041642016-09-07 Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream Langenfurth, Anika Gu, Song Bautze, Verena Zhang, Caiyi Neumann, Julia E. Schüller, Ulrich Stock, Kristin Wolf, Susanne A. Maier, Anna-Maria Mastrella, Giorgia Pak, Andrew Cheng, Hongwei Kälin, Roland E. Holmbeck, Kenn Strotmann, Jörg Kettenmann, Helmut Glass, Rainer Sci Rep Article The subventricular zone (SVZ) provides a constant supply of new neurons to the olfactory bulb (OB). Different studies have investigated the role of olfactory sensory input to neural precursor cell (NPC) turnover in the SVZ but it was not addressed if a reduced demand specifically for periglomerular neurons impacts on NPC-traits in the rostral migratory stream (RMS). We here report that membrane type-1 matrix metalloproteinase (MT1-MMP) deficient mice have reduced complexity of the nasal turbinates, decreased sensory innervation of the OB, reduced numbers of olfactory glomeruli and reduced OB-size without alterations in SVZ neurogenesis. Large parts of the RMS were fully preserved in MT1-MMP-deficient mice, but we detected an increase in cell death-levels and a decrease in SVZ-derived neuroblasts in the distal RMS, as compared to controls. BrdU-tracking experiments showed that homing of NPCs specifically to the glomerular layer was reduced in MT1-MMP-deficient mice in contrast to controls while numbers of tracked cells remained equal in other OB-layers throughout all experimental groups. Altogether, our data show the demand for olfactory interneurons in the glomerular layer modulates cell turnover in the RMS, but has no impact on subventricular neurogenesis. Nature Publishing Group 2016-08-30 /pmc/articles/PMC5004164/ /pubmed/27573347 http://dx.doi.org/10.1038/srep32203 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Langenfurth, Anika
Gu, Song
Bautze, Verena
Zhang, Caiyi
Neumann, Julia E.
Schüller, Ulrich
Stock, Kristin
Wolf, Susanne A.
Maier, Anna-Maria
Mastrella, Giorgia
Pak, Andrew
Cheng, Hongwei
Kälin, Roland E.
Holmbeck, Kenn
Strotmann, Jörg
Kettenmann, Helmut
Glass, Rainer
Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
title Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
title_full Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
title_fullStr Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
title_full_unstemmed Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
title_short Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
title_sort decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004164/
https://www.ncbi.nlm.nih.gov/pubmed/27573347
http://dx.doi.org/10.1038/srep32203
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