Radiotherapy for Non-Hodgkin’s lymphoma: still standard practice and not an outdated treatment option

Two large, recently published observational studies demonstate a clear down-trend in the use of radiotherapy (RT) over the last 15 years, both in the setting of follicular and diffuse large B-cell lymphoma. This change of practice might have a negative impact on clinical outcome. Even within the con...

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Autores principales: Zimmermann, Michel, Oehler, Christoph, Mey, Ulrich, Ghadjar, Pirus, Zwahlen, Daniel Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004297/
https://www.ncbi.nlm.nih.gov/pubmed/27577712
http://dx.doi.org/10.1186/s13014-016-0690-y
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author Zimmermann, Michel
Oehler, Christoph
Mey, Ulrich
Ghadjar, Pirus
Zwahlen, Daniel Rudolf
author_facet Zimmermann, Michel
Oehler, Christoph
Mey, Ulrich
Ghadjar, Pirus
Zwahlen, Daniel Rudolf
author_sort Zimmermann, Michel
collection PubMed
description Two large, recently published observational studies demonstate a clear down-trend in the use of radiotherapy (RT) over the last 15 years, both in the setting of follicular and diffuse large B-cell lymphoma. This change of practice might have a negative impact on clinical outcome. Even within the context of modern systemic therapy, omission of RT translates not only into a shorter progression-free survival (PFS), but also into a worse overall survival (OS). RT should therefore remain standard practice. This short review is aiming to summarize current guidelines and the best evidence available in the management of non-Hodgkin’s lymphoma. Potentially practice changing, ongoing trials will be highlighted.
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spelling pubmed-50042972016-08-31 Radiotherapy for Non-Hodgkin’s lymphoma: still standard practice and not an outdated treatment option Zimmermann, Michel Oehler, Christoph Mey, Ulrich Ghadjar, Pirus Zwahlen, Daniel Rudolf Radiat Oncol Review Two large, recently published observational studies demonstate a clear down-trend in the use of radiotherapy (RT) over the last 15 years, both in the setting of follicular and diffuse large B-cell lymphoma. This change of practice might have a negative impact on clinical outcome. Even within the context of modern systemic therapy, omission of RT translates not only into a shorter progression-free survival (PFS), but also into a worse overall survival (OS). RT should therefore remain standard practice. This short review is aiming to summarize current guidelines and the best evidence available in the management of non-Hodgkin’s lymphoma. Potentially practice changing, ongoing trials will be highlighted. BioMed Central 2016-08-30 /pmc/articles/PMC5004297/ /pubmed/27577712 http://dx.doi.org/10.1186/s13014-016-0690-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zimmermann, Michel
Oehler, Christoph
Mey, Ulrich
Ghadjar, Pirus
Zwahlen, Daniel Rudolf
Radiotherapy for Non-Hodgkin’s lymphoma: still standard practice and not an outdated treatment option
title Radiotherapy for Non-Hodgkin’s lymphoma: still standard practice and not an outdated treatment option
title_full Radiotherapy for Non-Hodgkin’s lymphoma: still standard practice and not an outdated treatment option
title_fullStr Radiotherapy for Non-Hodgkin’s lymphoma: still standard practice and not an outdated treatment option
title_full_unstemmed Radiotherapy for Non-Hodgkin’s lymphoma: still standard practice and not an outdated treatment option
title_short Radiotherapy for Non-Hodgkin’s lymphoma: still standard practice and not an outdated treatment option
title_sort radiotherapy for non-hodgkin’s lymphoma: still standard practice and not an outdated treatment option
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004297/
https://www.ncbi.nlm.nih.gov/pubmed/27577712
http://dx.doi.org/10.1186/s13014-016-0690-y
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