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Comparison of endoscopic based diagnosis with Helicobacter urease test for Helicobacter pylori infection
BACKGROUND: Helicobacter pylori is an important risk factor for gastritis, peptic ulcers and gastric cancer. The prevalence in developed countries is lower than 40 % but higher than 80 % in some developing countries. It is 75 % in Ghana. The Helicobacter urease test (HUT) is performed at endoscopy a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004304/ https://www.ncbi.nlm.nih.gov/pubmed/27576901 http://dx.doi.org/10.1186/s13104-016-2237-6 |
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author | Adu-Aryee, N. A. Aabakken, L. Dedey, F. Nsaful, J. Kudzi, W. |
author_facet | Adu-Aryee, N. A. Aabakken, L. Dedey, F. Nsaful, J. Kudzi, W. |
author_sort | Adu-Aryee, N. A. |
collection | PubMed |
description | BACKGROUND: Helicobacter pylori is an important risk factor for gastritis, peptic ulcers and gastric cancer. The prevalence in developed countries is lower than 40 % but higher than 80 % in some developing countries. It is 75 % in Ghana. The Helicobacter urease test (HUT) is performed at endoscopy and gives an accurate diagnosis. The HUT is not routinely done at our facility and presumption of H. pylori is made based on endoscopic findings and H. pylori eradication prescribed, as the incidence in the general population is presumed high. Is this endoscopic diagnosis sufficient for diagnosing and treating H. pylori? We aimed to assess the feasibility of an endoscopic based H. pylori diagnosis and its accuracy using a HUT as the gold standard in consecutive patients. METHODS: Seventy-six consecutive adult patients with dyspepsia were assessed by upper gastrointestinal endoscopy. A clinical diagnosis of H. pylori or not was made. Biopsy samples were collected for HUT. H. pylori was diagnosed if HUT was positive. The results were then compared. RESULTS: Median age of patients was 45.0 years. H. pylori prevalence detected by HUT was 51.3 % (95 % CI 40.0–63.0). Sensitivity of endoscopic diagnosis of H. pylori was 71.8 % (95 % CI 55.1–85.0) and specificity was 37.8 % (95 % CI 22.5–55.2). There was no association between clinical findings (73.7 %) and HUT (26.3 %) (OR = 0.80; [95 % CI 0.24–2.64], p = 0.682). There was also no association between endoscopic diagnosis (71.8 %) and HUT (28.2 %), (OR = 1.55; 95 % CI 0.59–4.06, p = 0.373). CONCLUSION: Helicobacter pylori infection was not as high as that published in earlier reports. The endoscopic diagnosis alone is not sufficient to make a diagnosis of H. pylori. |
format | Online Article Text |
id | pubmed-5004304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50043042016-08-31 Comparison of endoscopic based diagnosis with Helicobacter urease test for Helicobacter pylori infection Adu-Aryee, N. A. Aabakken, L. Dedey, F. Nsaful, J. Kudzi, W. BMC Res Notes Research Article BACKGROUND: Helicobacter pylori is an important risk factor for gastritis, peptic ulcers and gastric cancer. The prevalence in developed countries is lower than 40 % but higher than 80 % in some developing countries. It is 75 % in Ghana. The Helicobacter urease test (HUT) is performed at endoscopy and gives an accurate diagnosis. The HUT is not routinely done at our facility and presumption of H. pylori is made based on endoscopic findings and H. pylori eradication prescribed, as the incidence in the general population is presumed high. Is this endoscopic diagnosis sufficient for diagnosing and treating H. pylori? We aimed to assess the feasibility of an endoscopic based H. pylori diagnosis and its accuracy using a HUT as the gold standard in consecutive patients. METHODS: Seventy-six consecutive adult patients with dyspepsia were assessed by upper gastrointestinal endoscopy. A clinical diagnosis of H. pylori or not was made. Biopsy samples were collected for HUT. H. pylori was diagnosed if HUT was positive. The results were then compared. RESULTS: Median age of patients was 45.0 years. H. pylori prevalence detected by HUT was 51.3 % (95 % CI 40.0–63.0). Sensitivity of endoscopic diagnosis of H. pylori was 71.8 % (95 % CI 55.1–85.0) and specificity was 37.8 % (95 % CI 22.5–55.2). There was no association between clinical findings (73.7 %) and HUT (26.3 %) (OR = 0.80; [95 % CI 0.24–2.64], p = 0.682). There was also no association between endoscopic diagnosis (71.8 %) and HUT (28.2 %), (OR = 1.55; 95 % CI 0.59–4.06, p = 0.373). CONCLUSION: Helicobacter pylori infection was not as high as that published in earlier reports. The endoscopic diagnosis alone is not sufficient to make a diagnosis of H. pylori. BioMed Central 2016-08-30 /pmc/articles/PMC5004304/ /pubmed/27576901 http://dx.doi.org/10.1186/s13104-016-2237-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Adu-Aryee, N. A. Aabakken, L. Dedey, F. Nsaful, J. Kudzi, W. Comparison of endoscopic based diagnosis with Helicobacter urease test for Helicobacter pylori infection |
title | Comparison of endoscopic based diagnosis with Helicobacter urease test for Helicobacter pylori infection |
title_full | Comparison of endoscopic based diagnosis with Helicobacter urease test for Helicobacter pylori infection |
title_fullStr | Comparison of endoscopic based diagnosis with Helicobacter urease test for Helicobacter pylori infection |
title_full_unstemmed | Comparison of endoscopic based diagnosis with Helicobacter urease test for Helicobacter pylori infection |
title_short | Comparison of endoscopic based diagnosis with Helicobacter urease test for Helicobacter pylori infection |
title_sort | comparison of endoscopic based diagnosis with helicobacter urease test for helicobacter pylori infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004304/ https://www.ncbi.nlm.nih.gov/pubmed/27576901 http://dx.doi.org/10.1186/s13104-016-2237-6 |
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