Mitotic exit: Determining the PP2A dephosphorylation program

In mitotic exit, proteins that were highly phosphorylated are sequentially targeted by the phosphatase PP2A-B55, but what underlies substrate selection is unclear. In this issue, Cundell et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201606033) identify the determinants of PP2A-B55’s deph...

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Detalles Bibliográficos
Autores principales: Pereira, Gislene, Schiebel, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004451/
https://www.ncbi.nlm.nih.gov/pubmed/27551057
http://dx.doi.org/10.1083/jcb.201608019
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author Pereira, Gislene
Schiebel, Elmar
author_facet Pereira, Gislene
Schiebel, Elmar
author_sort Pereira, Gislene
collection PubMed
description In mitotic exit, proteins that were highly phosphorylated are sequentially targeted by the phosphatase PP2A-B55, but what underlies substrate selection is unclear. In this issue, Cundell et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201606033) identify the determinants of PP2A-B55’s dephosphorylation program, thereby influencing spindle disassembly, nuclear envelope reformation, and cytokinesis.
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spelling pubmed-50044512017-02-28 Mitotic exit: Determining the PP2A dephosphorylation program Pereira, Gislene Schiebel, Elmar J Cell Biol Commentary In mitotic exit, proteins that were highly phosphorylated are sequentially targeted by the phosphatase PP2A-B55, but what underlies substrate selection is unclear. In this issue, Cundell et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201606033) identify the determinants of PP2A-B55’s dephosphorylation program, thereby influencing spindle disassembly, nuclear envelope reformation, and cytokinesis. The Rockefeller University Press 2016-08-29 /pmc/articles/PMC5004451/ /pubmed/27551057 http://dx.doi.org/10.1083/jcb.201608019 Text en © 2016 Pereira and Schiebel This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Pereira, Gislene
Schiebel, Elmar
Mitotic exit: Determining the PP2A dephosphorylation program
title Mitotic exit: Determining the PP2A dephosphorylation program
title_full Mitotic exit: Determining the PP2A dephosphorylation program
title_fullStr Mitotic exit: Determining the PP2A dephosphorylation program
title_full_unstemmed Mitotic exit: Determining the PP2A dephosphorylation program
title_short Mitotic exit: Determining the PP2A dephosphorylation program
title_sort mitotic exit: determining the pp2a dephosphorylation program
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004451/
https://www.ncbi.nlm.nih.gov/pubmed/27551057
http://dx.doi.org/10.1083/jcb.201608019
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