The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells, enabling viral RNA replication and counteracting host antiviral responses. Here, we demonstrate a novel function of NS5 in the nucleus where it interferes with cellular splicing. Using global proteomic analysis of...

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Detalles Bibliográficos
Autores principales: De Maio, Federico A., Risso, Guillermo, Iglesias, Nestor G., Shah, Priya, Pozzi, Berta, Gebhard, Leopoldo G., Mammi, Pablo, Mancini, Estefania, Yanovsky, Marcelo J., Andino, Raul, Krogan, Nevan, Srebrow, Anabella, Gamarnik, Andrea V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004807/
https://www.ncbi.nlm.nih.gov/pubmed/27575636
http://dx.doi.org/10.1371/journal.ppat.1005841

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