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Short Time-Scale Sensory Coding in S1 during Discrimination of Whisker Vibrotactile Sequences
Rodent whisker input consists of dense microvibration sequences that are often temporally integrated for perceptual discrimination. Whether primary somatosensory cortex (S1) participates in temporal integration is unknown. We trained rats to discriminate whisker impulse sequences that varied in sing...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004814/ https://www.ncbi.nlm.nih.gov/pubmed/27574970 http://dx.doi.org/10.1371/journal.pbio.1002549 |
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author | McGuire, Leah M. Telian, Gregory Laboy-Juárez, Keven J. Miyashita, Toshio Lee, Daniel J. Smith, Katherine A. Feldman, Daniel E. |
author_facet | McGuire, Leah M. Telian, Gregory Laboy-Juárez, Keven J. Miyashita, Toshio Lee, Daniel J. Smith, Katherine A. Feldman, Daniel E. |
author_sort | McGuire, Leah M. |
collection | PubMed |
description | Rodent whisker input consists of dense microvibration sequences that are often temporally integrated for perceptual discrimination. Whether primary somatosensory cortex (S1) participates in temporal integration is unknown. We trained rats to discriminate whisker impulse sequences that varied in single-impulse kinematics (5–20-ms time scale) and mean speed (150-ms time scale). Rats appeared to use the integrated feature, mean speed, to guide discrimination in this task, consistent with similar prior studies. Despite this, 52% of S1 units, including 73% of units in L4 and L2/3, encoded sequences at fast time scales (≤20 ms, mostly 5–10 ms), accurately reflecting single impulse kinematics. 17% of units, mostly in L5, showed weaker impulse responses and a slow firing rate increase during sequences. However, these units did not effectively integrate whisker impulses, but instead combined weak impulse responses with a distinct, slow signal correlated to behavioral choice. A neural decoder could identify sequences from fast unit spike trains and behavioral choice from slow units. Thus, S1 encoded fast time scale whisker input without substantial temporal integration across whisker impulses. |
format | Online Article Text |
id | pubmed-5004814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50048142016-09-12 Short Time-Scale Sensory Coding in S1 during Discrimination of Whisker Vibrotactile Sequences McGuire, Leah M. Telian, Gregory Laboy-Juárez, Keven J. Miyashita, Toshio Lee, Daniel J. Smith, Katherine A. Feldman, Daniel E. PLoS Biol Research Article Rodent whisker input consists of dense microvibration sequences that are often temporally integrated for perceptual discrimination. Whether primary somatosensory cortex (S1) participates in temporal integration is unknown. We trained rats to discriminate whisker impulse sequences that varied in single-impulse kinematics (5–20-ms time scale) and mean speed (150-ms time scale). Rats appeared to use the integrated feature, mean speed, to guide discrimination in this task, consistent with similar prior studies. Despite this, 52% of S1 units, including 73% of units in L4 and L2/3, encoded sequences at fast time scales (≤20 ms, mostly 5–10 ms), accurately reflecting single impulse kinematics. 17% of units, mostly in L5, showed weaker impulse responses and a slow firing rate increase during sequences. However, these units did not effectively integrate whisker impulses, but instead combined weak impulse responses with a distinct, slow signal correlated to behavioral choice. A neural decoder could identify sequences from fast unit spike trains and behavioral choice from slow units. Thus, S1 encoded fast time scale whisker input without substantial temporal integration across whisker impulses. Public Library of Science 2016-08-30 /pmc/articles/PMC5004814/ /pubmed/27574970 http://dx.doi.org/10.1371/journal.pbio.1002549 Text en © 2016 McGuire et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article McGuire, Leah M. Telian, Gregory Laboy-Juárez, Keven J. Miyashita, Toshio Lee, Daniel J. Smith, Katherine A. Feldman, Daniel E. Short Time-Scale Sensory Coding in S1 during Discrimination of Whisker Vibrotactile Sequences |
title | Short Time-Scale Sensory Coding in S1 during Discrimination of Whisker Vibrotactile Sequences |
title_full | Short Time-Scale Sensory Coding in S1 during Discrimination of Whisker Vibrotactile Sequences |
title_fullStr | Short Time-Scale Sensory Coding in S1 during Discrimination of Whisker Vibrotactile Sequences |
title_full_unstemmed | Short Time-Scale Sensory Coding in S1 during Discrimination of Whisker Vibrotactile Sequences |
title_short | Short Time-Scale Sensory Coding in S1 during Discrimination of Whisker Vibrotactile Sequences |
title_sort | short time-scale sensory coding in s1 during discrimination of whisker vibrotactile sequences |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004814/ https://www.ncbi.nlm.nih.gov/pubmed/27574970 http://dx.doi.org/10.1371/journal.pbio.1002549 |
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