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Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population
The functional variant of the Klotho "KL-VS" stretch, which includes six polymorphisms in linkage disequilibrium, is reportedly associated with healthy aging and longevity in European and American populations. Among Asian populations, this variant has been observed in the Indian population...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Genética
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004824/ https://www.ncbi.nlm.nih.gov/pubmed/27560364 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0160 |
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author | Kim, Hee-Kwon Jeong, Byung-Hoon |
author_facet | Kim, Hee-Kwon Jeong, Byung-Hoon |
author_sort | Kim, Hee-Kwon |
collection | PubMed |
description | The functional variant of the Klotho "KL-VS" stretch, which includes six polymorphisms in linkage disequilibrium, is reportedly associated with healthy aging and longevity in European and American populations. Among Asian populations, this variant has been observed in the Indian population but not in the Iranian population. An association between KL-VS polymorphism and aging has not been reported in Koreans. To investigate whether the KL-VS polymorphism could be associated with healthy aging and longevity in a Korean population, we analyzed genotype and allele frequencies of the KL-VS variant in a large Korean population sample. The KL-VS variant was not found in 874 Korean individuals. Thus, it is not possible to test its association to aging in the East Asian populations. |
format | Online Article Text |
id | pubmed-5004824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-50048242016-09-13 Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population Kim, Hee-Kwon Jeong, Byung-Hoon Genet Mol Biol Human and Medical Genetics The functional variant of the Klotho "KL-VS" stretch, which includes six polymorphisms in linkage disequilibrium, is reportedly associated with healthy aging and longevity in European and American populations. Among Asian populations, this variant has been observed in the Indian population but not in the Iranian population. An association between KL-VS polymorphism and aging has not been reported in Koreans. To investigate whether the KL-VS polymorphism could be associated with healthy aging and longevity in a Korean population, we analyzed genotype and allele frequencies of the KL-VS variant in a large Korean population sample. The KL-VS variant was not found in 874 Korean individuals. Thus, it is not possible to test its association to aging in the East Asian populations. Sociedade Brasileira de Genética 2016-06-16 2016 /pmc/articles/PMC5004824/ /pubmed/27560364 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0160 Text en Copyright © 2016, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited. |
spellingShingle | Human and Medical Genetics Kim, Hee-Kwon Jeong, Byung-Hoon Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population |
title | Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population |
title_full | Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population |
title_fullStr | Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population |
title_full_unstemmed | Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population |
title_short | Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population |
title_sort | lack of functional kl-vs polymorphism of the klotho gene in the korean population |
topic | Human and Medical Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004824/ https://www.ncbi.nlm.nih.gov/pubmed/27560364 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0160 |
work_keys_str_mv | AT kimheekwon lackoffunctionalklvspolymorphismoftheklothogeneinthekoreanpopulation AT jeongbyunghoon lackoffunctionalklvspolymorphismoftheklothogeneinthekoreanpopulation |