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Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population

The functional variant of the Klotho "KL-VS" stretch, which includes six polymorphisms in linkage disequilibrium, is reportedly associated with healthy aging and longevity in European and American populations. Among Asian populations, this variant has been observed in the Indian population...

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Autores principales: Kim, Hee-Kwon, Jeong, Byung-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004824/
https://www.ncbi.nlm.nih.gov/pubmed/27560364
http://dx.doi.org/10.1590/1678-4685-GMB-2015-0160
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author Kim, Hee-Kwon
Jeong, Byung-Hoon
author_facet Kim, Hee-Kwon
Jeong, Byung-Hoon
author_sort Kim, Hee-Kwon
collection PubMed
description The functional variant of the Klotho "KL-VS" stretch, which includes six polymorphisms in linkage disequilibrium, is reportedly associated with healthy aging and longevity in European and American populations. Among Asian populations, this variant has been observed in the Indian population but not in the Iranian population. An association between KL-VS polymorphism and aging has not been reported in Koreans. To investigate whether the KL-VS polymorphism could be associated with healthy aging and longevity in a Korean population, we analyzed genotype and allele frequencies of the KL-VS variant in a large Korean population sample. The KL-VS variant was not found in 874 Korean individuals. Thus, it is not possible to test its association to aging in the East Asian populations.
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spelling pubmed-50048242016-09-13 Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population Kim, Hee-Kwon Jeong, Byung-Hoon Genet Mol Biol Human and Medical Genetics The functional variant of the Klotho "KL-VS" stretch, which includes six polymorphisms in linkage disequilibrium, is reportedly associated with healthy aging and longevity in European and American populations. Among Asian populations, this variant has been observed in the Indian population but not in the Iranian population. An association between KL-VS polymorphism and aging has not been reported in Koreans. To investigate whether the KL-VS polymorphism could be associated with healthy aging and longevity in a Korean population, we analyzed genotype and allele frequencies of the KL-VS variant in a large Korean population sample. The KL-VS variant was not found in 874 Korean individuals. Thus, it is not possible to test its association to aging in the East Asian populations. Sociedade Brasileira de Genética 2016-06-16 2016 /pmc/articles/PMC5004824/ /pubmed/27560364 http://dx.doi.org/10.1590/1678-4685-GMB-2015-0160 Text en Copyright © 2016, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Human and Medical Genetics
Kim, Hee-Kwon
Jeong, Byung-Hoon
Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population
title Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population
title_full Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population
title_fullStr Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population
title_full_unstemmed Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population
title_short Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population
title_sort lack of functional kl-vs polymorphism of the klotho gene in the korean population
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004824/
https://www.ncbi.nlm.nih.gov/pubmed/27560364
http://dx.doi.org/10.1590/1678-4685-GMB-2015-0160
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