Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs

The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here, we characterise AEBP2, a known PRC2 co-factor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, inc...

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Detalles Bibliográficos
Autores principales: Grijzenhout, Anne, Godwin, Jonathan, Koseki, Haruhiko, Gdula, Michal Ryszard, Szumska, Dorota, McGouran, Joanna F., Bhattacharya, Shoumo, Kessler, Benedikt M., Brockdorff, Neil, Cooper, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Stem Cells and Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004903/
https://www.ncbi.nlm.nih.gov/pubmed/27317809
http://dx.doi.org/10.1242/dev.123935

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