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Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients

OBJECTIVE: Reduced verbal fluency (VF) has been reported in patients with Parkinson’s disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modifi...

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Autores principales: Vonberg, Isabelle, Ehlen, Felicitas, Fromm, Ortwin, Kühn, Andrea A., Klostermann, Fabian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004923/
https://www.ncbi.nlm.nih.gov/pubmed/27575379
http://dx.doi.org/10.1371/journal.pone.0161404
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author Vonberg, Isabelle
Ehlen, Felicitas
Fromm, Ortwin
Kühn, Andrea A.
Klostermann, Fabian
author_facet Vonberg, Isabelle
Ehlen, Felicitas
Fromm, Ortwin
Kühn, Andrea A.
Klostermann, Fabian
author_sort Vonberg, Isabelle
collection PubMed
description OBJECTIVE: Reduced verbal fluency (VF) has been reported in patients with Parkinson’s disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modified by STN DBS. METHOD: Eleven PD patients performed VF tasks in their STN DBS ON and OFF condition. To differentiate VF-components modulated by the stimulation, a temporal cluster analysis was performed, separating production spurts (i.e., ‘clusters’ as correlates of automatic activation spread within lexical fields) from slower cluster transitions (i.e., ‘switches’ reflecting set-shifting towards new lexical fields). The results were compared to those of eleven healthy control subjects. RESULTS: PD patients produced significantly more switches accompanied by shorter switch times in the STN DBS ON compared to the STN DBS OFF condition. The number of clusters and time intervals between words within clusters were not affected by the treatment state. Although switch behavior in patients with DBS ON improved, their task performance was still lower compared to that of healthy controls. DISCUSSION: Beyond impacting on motor symptoms, STN DBS seems to influence the dynamics of cognitive procedures. Specifically, the results are in line with basal ganglia roles for cognitive switching, in the particular case of VF, from prevailing lexical concepts to new ones.
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spelling pubmed-50049232016-09-12 Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients Vonberg, Isabelle Ehlen, Felicitas Fromm, Ortwin Kühn, Andrea A. Klostermann, Fabian PLoS One Research Article OBJECTIVE: Reduced verbal fluency (VF) has been reported in patients with Parkinson’s disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modified by STN DBS. METHOD: Eleven PD patients performed VF tasks in their STN DBS ON and OFF condition. To differentiate VF-components modulated by the stimulation, a temporal cluster analysis was performed, separating production spurts (i.e., ‘clusters’ as correlates of automatic activation spread within lexical fields) from slower cluster transitions (i.e., ‘switches’ reflecting set-shifting towards new lexical fields). The results were compared to those of eleven healthy control subjects. RESULTS: PD patients produced significantly more switches accompanied by shorter switch times in the STN DBS ON compared to the STN DBS OFF condition. The number of clusters and time intervals between words within clusters were not affected by the treatment state. Although switch behavior in patients with DBS ON improved, their task performance was still lower compared to that of healthy controls. DISCUSSION: Beyond impacting on motor symptoms, STN DBS seems to influence the dynamics of cognitive procedures. Specifically, the results are in line with basal ganglia roles for cognitive switching, in the particular case of VF, from prevailing lexical concepts to new ones. Public Library of Science 2016-08-30 /pmc/articles/PMC5004923/ /pubmed/27575379 http://dx.doi.org/10.1371/journal.pone.0161404 Text en © 2016 Vonberg et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Vonberg, Isabelle
Ehlen, Felicitas
Fromm, Ortwin
Kühn, Andrea A.
Klostermann, Fabian
Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients
title Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients
title_full Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients
title_fullStr Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients
title_full_unstemmed Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients
title_short Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients
title_sort deep brain stimulation of the subthalamic nucleus improves lexical switching in parkinsons disease patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004923/
https://www.ncbi.nlm.nih.gov/pubmed/27575379
http://dx.doi.org/10.1371/journal.pone.0161404
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