MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs

Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim). Transcription factors (EBNAs) encoded by the lymphoma-associated Epstein-Barr virus (EBV) activate MYC and silence BCL2L11. We show t...

Descripción completa

Detalles Bibliográficos
Autores principales: Wood, C David, Veenstra, Hildegonda, Khasnis, Sarika, Gunnell, Andrea, Webb, Helen M, Shannon-Lowe, Claire, Andrews, Simon, Osborne, Cameron S, West, Michelle J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005034/
https://www.ncbi.nlm.nih.gov/pubmed/27490482
http://dx.doi.org/10.7554/eLife.18270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005034/
https://www.ncbi.nlm.nih.gov/pubmed/27490482
http://dx.doi.org/10.7554/eLife.18270

Ejemplares similares