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MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs
Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim). Transcription factors (EBNAs) encoded by the lymphoma-associated Epstein-Barr virus (EBV) activate MYC and silence BCL2L11. We show t...
Autores principales: | Wood, C David, Veenstra, Hildegonda, Khasnis, Sarika, Gunnell, Andrea, Webb, Helen M, Shannon-Lowe, Claire, Andrews, Simon, Osborne, Cameron S, West, Michelle J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005034/ https://www.ncbi.nlm.nih.gov/pubmed/27490482 http://dx.doi.org/10.7554/eLife.18270 |
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