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Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions
BACKGROUND: Keratocystic odontogenic tumor (KCOT) is a clinically significant cystic lesion of odontogenic origin. This study aimed to retrospectively review and describe the clinicopathologic features of KCOT and to objectively compare the clinical and histological features of solitary, multiple an...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medicina Oral S.L.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005089/ https://www.ncbi.nlm.nih.gov/pubmed/27475695 http://dx.doi.org/10.4317/medoral.21181 |
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author | Bello, Ibrahim-Olajide |
author_facet | Bello, Ibrahim-Olajide |
author_sort | Bello, Ibrahim-Olajide |
collection | PubMed |
description | BACKGROUND: Keratocystic odontogenic tumor (KCOT) is a clinically significant cystic lesion of odontogenic origin. This study aimed to retrospectively review and describe the clinicopathologic features of KCOT and to objectively compare the clinical and histological features of solitary, multiple and recurrent KCOT in a Saudi Arabian population. MATERIAL AND METHODS: Biopsy request forms, pathology records and archival materials (all histological slides) of 104 cases of KCOT from 75 patients were retrieved. Demographic and clinical details as well as histological evaluation were analyzed and compared between the 3 groups using chi-squared or Mann-Whitney tests of association as appropriate. RESULTS: Significant differences were noted in the age of presentation, location and association with impaction between multiple and solitary cases. Histologically, there was a difference in the mitotic count, presence of satellite cysts and proliferating odontogenic epithelium between solitary and multiple lesions. There was no difference between the KCOT that later recurred and solitary lesion which did not recur even when matched clinically for age, sex and location. There were differences when solitary KCOT that later recurred or recurrent KCOT were compared with multiple lesions. Multiple lesions still had more significant proliferative activity parameters than solitary recurrence-related KCOT. CONCLUSIONS: KCOTs in Saudi Arabians are not different from those reported from other parts of the world. Clinical and histological analyses showed multiple KCOT is different from its solitary recurrent or non-recurrent counterparts and has a higher proliferative activity than both. Clinicohistologic features alone cannot wholly explain the behavior of KCOT. Key words:Descriptive study, keratocystic odontogenic tumor, odontogenic keratocyst, solitary, multiple, recurrent. |
format | Online Article Text |
id | pubmed-5005089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50050892016-09-01 Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions Bello, Ibrahim-Olajide Med Oral Patol Oral Cir Bucal Research BACKGROUND: Keratocystic odontogenic tumor (KCOT) is a clinically significant cystic lesion of odontogenic origin. This study aimed to retrospectively review and describe the clinicopathologic features of KCOT and to objectively compare the clinical and histological features of solitary, multiple and recurrent KCOT in a Saudi Arabian population. MATERIAL AND METHODS: Biopsy request forms, pathology records and archival materials (all histological slides) of 104 cases of KCOT from 75 patients were retrieved. Demographic and clinical details as well as histological evaluation were analyzed and compared between the 3 groups using chi-squared or Mann-Whitney tests of association as appropriate. RESULTS: Significant differences were noted in the age of presentation, location and association with impaction between multiple and solitary cases. Histologically, there was a difference in the mitotic count, presence of satellite cysts and proliferating odontogenic epithelium between solitary and multiple lesions. There was no difference between the KCOT that later recurred and solitary lesion which did not recur even when matched clinically for age, sex and location. There were differences when solitary KCOT that later recurred or recurrent KCOT were compared with multiple lesions. Multiple lesions still had more significant proliferative activity parameters than solitary recurrence-related KCOT. CONCLUSIONS: KCOTs in Saudi Arabians are not different from those reported from other parts of the world. Clinical and histological analyses showed multiple KCOT is different from its solitary recurrent or non-recurrent counterparts and has a higher proliferative activity than both. Clinicohistologic features alone cannot wholly explain the behavior of KCOT. Key words:Descriptive study, keratocystic odontogenic tumor, odontogenic keratocyst, solitary, multiple, recurrent. Medicina Oral S.L. 2016-09 2016-07-31 /pmc/articles/PMC5005089/ /pubmed/27475695 http://dx.doi.org/10.4317/medoral.21181 Text en Copyright: © 2016 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Bello, Ibrahim-Olajide Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions |
title | Keratocystic odontogenic tumor: A biopsy service’s experience
with 104 solitary, multiple and recurrent lesions |
title_full | Keratocystic odontogenic tumor: A biopsy service’s experience
with 104 solitary, multiple and recurrent lesions |
title_fullStr | Keratocystic odontogenic tumor: A biopsy service’s experience
with 104 solitary, multiple and recurrent lesions |
title_full_unstemmed | Keratocystic odontogenic tumor: A biopsy service’s experience
with 104 solitary, multiple and recurrent lesions |
title_short | Keratocystic odontogenic tumor: A biopsy service’s experience
with 104 solitary, multiple and recurrent lesions |
title_sort | keratocystic odontogenic tumor: a biopsy service’s experience
with 104 solitary, multiple and recurrent lesions |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005089/ https://www.ncbi.nlm.nih.gov/pubmed/27475695 http://dx.doi.org/10.4317/medoral.21181 |
work_keys_str_mv | AT belloibrahimolajide keratocysticodontogenictumorabiopsyservicesexperiencewith104solitarymultipleandrecurrentlesions |