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Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions

BACKGROUND: Keratocystic odontogenic tumor (KCOT) is a clinically significant cystic lesion of odontogenic origin. This study aimed to retrospectively review and describe the clinicopathologic features of KCOT and to objectively compare the clinical and histological features of solitary, multiple an...

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Autor principal: Bello, Ibrahim-Olajide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005089/
https://www.ncbi.nlm.nih.gov/pubmed/27475695
http://dx.doi.org/10.4317/medoral.21181
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author Bello, Ibrahim-Olajide
author_facet Bello, Ibrahim-Olajide
author_sort Bello, Ibrahim-Olajide
collection PubMed
description BACKGROUND: Keratocystic odontogenic tumor (KCOT) is a clinically significant cystic lesion of odontogenic origin. This study aimed to retrospectively review and describe the clinicopathologic features of KCOT and to objectively compare the clinical and histological features of solitary, multiple and recurrent KCOT in a Saudi Arabian population. MATERIAL AND METHODS: Biopsy request forms, pathology records and archival materials (all histological slides) of 104 cases of KCOT from 75 patients were retrieved. Demographic and clinical details as well as histological evaluation were analyzed and compared between the 3 groups using chi-squared or Mann-Whitney tests of association as appropriate. RESULTS: Significant differences were noted in the age of presentation, location and association with impaction between multiple and solitary cases. Histologically, there was a difference in the mitotic count, presence of satellite cysts and proliferating odontogenic epithelium between solitary and multiple lesions. There was no difference between the KCOT that later recurred and solitary lesion which did not recur even when matched clinically for age, sex and location. There were differences when solitary KCOT that later recurred or recurrent KCOT were compared with multiple lesions. Multiple lesions still had more significant proliferative activity parameters than solitary recurrence-related KCOT. CONCLUSIONS: KCOTs in Saudi Arabians are not different from those reported from other parts of the world. Clinical and histological analyses showed multiple KCOT is different from its solitary recurrent or non-recurrent counterparts and has a higher proliferative activity than both. Clinicohistologic features alone cannot wholly explain the behavior of KCOT. Key words:Descriptive study, keratocystic odontogenic tumor, odontogenic keratocyst, solitary, multiple, recurrent.
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spelling pubmed-50050892016-09-01 Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions Bello, Ibrahim-Olajide Med Oral Patol Oral Cir Bucal Research BACKGROUND: Keratocystic odontogenic tumor (KCOT) is a clinically significant cystic lesion of odontogenic origin. This study aimed to retrospectively review and describe the clinicopathologic features of KCOT and to objectively compare the clinical and histological features of solitary, multiple and recurrent KCOT in a Saudi Arabian population. MATERIAL AND METHODS: Biopsy request forms, pathology records and archival materials (all histological slides) of 104 cases of KCOT from 75 patients were retrieved. Demographic and clinical details as well as histological evaluation were analyzed and compared between the 3 groups using chi-squared or Mann-Whitney tests of association as appropriate. RESULTS: Significant differences were noted in the age of presentation, location and association with impaction between multiple and solitary cases. Histologically, there was a difference in the mitotic count, presence of satellite cysts and proliferating odontogenic epithelium between solitary and multiple lesions. There was no difference between the KCOT that later recurred and solitary lesion which did not recur even when matched clinically for age, sex and location. There were differences when solitary KCOT that later recurred or recurrent KCOT were compared with multiple lesions. Multiple lesions still had more significant proliferative activity parameters than solitary recurrence-related KCOT. CONCLUSIONS: KCOTs in Saudi Arabians are not different from those reported from other parts of the world. Clinical and histological analyses showed multiple KCOT is different from its solitary recurrent or non-recurrent counterparts and has a higher proliferative activity than both. Clinicohistologic features alone cannot wholly explain the behavior of KCOT. Key words:Descriptive study, keratocystic odontogenic tumor, odontogenic keratocyst, solitary, multiple, recurrent. Medicina Oral S.L. 2016-09 2016-07-31 /pmc/articles/PMC5005089/ /pubmed/27475695 http://dx.doi.org/10.4317/medoral.21181 Text en Copyright: © 2016 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Bello, Ibrahim-Olajide
Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions
title Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions
title_full Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions
title_fullStr Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions
title_full_unstemmed Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions
title_short Keratocystic odontogenic tumor: A biopsy service’s experience with 104 solitary, multiple and recurrent lesions
title_sort keratocystic odontogenic tumor: a biopsy service’s experience with 104 solitary, multiple and recurrent lesions
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005089/
https://www.ncbi.nlm.nih.gov/pubmed/27475695
http://dx.doi.org/10.4317/medoral.21181
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