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Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study

BACKGROUND: Takotsubo cardiomyopathy (TTC) is characterised by transient contractility disturbances of the apex of the left ventricle. METHODS: We enrolled 101 patients from the northern-eastern part of Poland in the years 2008–2012 who were hospitalised for TCC. The control group consisted of femal...

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Autores principales: Zalewska-Adamiec, M., Bachorzewska-Gajewska, H., Tomaszuk-Kazberuk, A., Nowak, K., Drozdowski, P., Bychowski, J., Krynicki, R., Musial, W. J., Dobrzycki, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bohn Stafleu van Loghum 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005189/
https://www.ncbi.nlm.nih.gov/pubmed/27401602
http://dx.doi.org/10.1007/s12471-016-0857-z
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author Zalewska-Adamiec, M.
Bachorzewska-Gajewska, H.
Tomaszuk-Kazberuk, A.
Nowak, K.
Drozdowski, P.
Bychowski, J.
Krynicki, R.
Musial, W. J.
Dobrzycki, S.
author_facet Zalewska-Adamiec, M.
Bachorzewska-Gajewska, H.
Tomaszuk-Kazberuk, A.
Nowak, K.
Drozdowski, P.
Bychowski, J.
Krynicki, R.
Musial, W. J.
Dobrzycki, S.
author_sort Zalewska-Adamiec, M.
collection PubMed
description BACKGROUND: Takotsubo cardiomyopathy (TTC) is characterised by transient contractility disturbances of the apex of the left ventricle. METHODS: We enrolled 101 patients from the northern-eastern part of Poland in the years 2008–2012 who were hospitalised for TCC. The control group consisted of female patients diagnosed with anterior myocardial infarction with ST-segment elevation (anterior STEMI) (n = 101). RESULTS: 89 % of the study group were women. Patients with TTC had diabetes (12.6 % vs 29.7 %; p = 0.002) and hyperlipidaemia (36.8 % vs 64.4 %; p = 0.0001) significantly less frequently, and better kidney function assessed by estimated glomerular filtration rate versus patients with anterior STEMI (74.52 % vs 64.30 %; p = 0.004). In the TTC group there were more patients with chronic obstructive pulmonary disease (11.6 % vs 1.0 %; p = 0.002) and thyroid disturbances, especially hyperthyroidism (23.4 % vs 11.0 %; p = 0.021). In patients with TTC sudden cardiac arrest, pulmonary oedema and cardiogenic shock were observed less frequently than in the control group (14.7 % vs 30.7 %; p = 0.0078). Hospitalisations in TTC patients were less frequently complicated by pneumonia (20.0 % vs 35.6 %; p = 0.0148) and urinary infection (4.2 % vs 21.8 %; p = 0.0003). Cardiac rupture occurred in 3 patients with TTC and in 1 with anterior STEMI. In-hospital mortality was significantly lower in the group with TTC. Also, mortality at 30 days, 3 months, 1 year and 2.5 years was significantly lower in patients with TTC than in patients with MI (p = 0.035; p = 0.0226; p = 0.0075; p = 0.009). CONCLUSIONS: Previously considered to be a benign syndrome, TTC should be reconsidered as a clinical condition at risk for serious complications such as cardiac arrest, cardiogenic shock, pulmonary oedema and cardiac rupture leading to death and causing substantial early hazard. The prognosis in TTC is significantly better than in patients with anterior STEMI.
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spelling pubmed-50051892016-09-15 Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study Zalewska-Adamiec, M. Bachorzewska-Gajewska, H. Tomaszuk-Kazberuk, A. Nowak, K. Drozdowski, P. Bychowski, J. Krynicki, R. Musial, W. J. Dobrzycki, S. Neth Heart J Original Article - Design Study Article BACKGROUND: Takotsubo cardiomyopathy (TTC) is characterised by transient contractility disturbances of the apex of the left ventricle. METHODS: We enrolled 101 patients from the northern-eastern part of Poland in the years 2008–2012 who were hospitalised for TCC. The control group consisted of female patients diagnosed with anterior myocardial infarction with ST-segment elevation (anterior STEMI) (n = 101). RESULTS: 89 % of the study group were women. Patients with TTC had diabetes (12.6 % vs 29.7 %; p = 0.002) and hyperlipidaemia (36.8 % vs 64.4 %; p = 0.0001) significantly less frequently, and better kidney function assessed by estimated glomerular filtration rate versus patients with anterior STEMI (74.52 % vs 64.30 %; p = 0.004). In the TTC group there were more patients with chronic obstructive pulmonary disease (11.6 % vs 1.0 %; p = 0.002) and thyroid disturbances, especially hyperthyroidism (23.4 % vs 11.0 %; p = 0.021). In patients with TTC sudden cardiac arrest, pulmonary oedema and cardiogenic shock were observed less frequently than in the control group (14.7 % vs 30.7 %; p = 0.0078). Hospitalisations in TTC patients were less frequently complicated by pneumonia (20.0 % vs 35.6 %; p = 0.0148) and urinary infection (4.2 % vs 21.8 %; p = 0.0003). Cardiac rupture occurred in 3 patients with TTC and in 1 with anterior STEMI. In-hospital mortality was significantly lower in the group with TTC. Also, mortality at 30 days, 3 months, 1 year and 2.5 years was significantly lower in patients with TTC than in patients with MI (p = 0.035; p = 0.0226; p = 0.0075; p = 0.009). CONCLUSIONS: Previously considered to be a benign syndrome, TTC should be reconsidered as a clinical condition at risk for serious complications such as cardiac arrest, cardiogenic shock, pulmonary oedema and cardiac rupture leading to death and causing substantial early hazard. The prognosis in TTC is significantly better than in patients with anterior STEMI. Bohn Stafleu van Loghum 2016-07-11 2016-09 /pmc/articles/PMC5005189/ /pubmed/27401602 http://dx.doi.org/10.1007/s12471-016-0857-z Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article - Design Study Article
Zalewska-Adamiec, M.
Bachorzewska-Gajewska, H.
Tomaszuk-Kazberuk, A.
Nowak, K.
Drozdowski, P.
Bychowski, J.
Krynicki, R.
Musial, W. J.
Dobrzycki, S.
Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study
title Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study
title_full Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study
title_fullStr Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study
title_full_unstemmed Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study
title_short Takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study
title_sort takotsubo cardiomyopathy: serious early complications and two-year mortality – a 101 case study
topic Original Article - Design Study Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005189/
https://www.ncbi.nlm.nih.gov/pubmed/27401602
http://dx.doi.org/10.1007/s12471-016-0857-z
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