Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model

Despite the use of ionizing radiation (IR) and temozolomide (TMZ), outcome for glioblastoma (GBM) patients remains dismal. Poly (ADP-ribose) polymerase (PARP) is important in repair pathways for IR-induced DNA damage and TMZ-induced alkylation at N7-methylguanine and N3-methyldenine. However, optimi...

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Detalles Bibliográficos
Autores principales: Lemasson, Benjamin, Wang, Hanxiao, Galbán, Stefanie, Li, Yinghua, Zhu, Yuan, Heist, Kevin A., Tsein, Christina, Chenevert, Thomas L., Rehemtulla, Alnawaz, Galbán, Craig J., Holland, Eric C., Ross, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005260/
https://www.ncbi.nlm.nih.gov/pubmed/26936394
http://dx.doi.org/10.1016/j.neo.2015.11.014

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