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Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology
BACKGROUND: Extraction conditions greatly affect composition, as well as biological activity. Therefore, optimization is essential for maximum efficacy. METHODS: Korean Red Ginseng (KRG) was extracted under different conditions and antioxidant activity, extraction yield, and ginsenoside Rg1 and phen...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005304/ https://www.ncbi.nlm.nih.gov/pubmed/27616898 http://dx.doi.org/10.1016/j.jgr.2015.08.001 |
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author | Lee, Jin Woo Mo, Eun Jin Choi, Ji Eun Jo, Yang Hee Jang, Hari Jeong, Ji Yeon Jin, Qinghao Chung, Hee Nam Hwang, Bang Yeon Lee, Mi Kyeong |
author_facet | Lee, Jin Woo Mo, Eun Jin Choi, Ji Eun Jo, Yang Hee Jang, Hari Jeong, Ji Yeon Jin, Qinghao Chung, Hee Nam Hwang, Bang Yeon Lee, Mi Kyeong |
author_sort | Lee, Jin Woo |
collection | PubMed |
description | BACKGROUND: Extraction conditions greatly affect composition, as well as biological activity. Therefore, optimization is essential for maximum efficacy. METHODS: Korean Red Ginseng (KRG) was extracted under different conditions and antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content evaluated. Optimized extraction conditions were suggested using response surface methodology for maximum antioxidant activity and extraction yield. RESULTS: Analysis of KRG extraction conditions using response surface methodology showed a good fit of experimental data as demonstrated by regression analysis. Among extraction factors, such as extraction solvent and extraction time and temperature, ethanol concentration greatly affected antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content. The optimal conditions for maximum antioxidant activity and extraction yield were an ethanol concentration of 48.8%, an extraction time 73.3 min, and an extraction temperature of 90°C. The antioxidant activity and extraction yield under optimal conditions were 43.7% and 23.2% of dried KRG, respectively. CONCLUSION: Ethanol concentration is an important extraction factor for KRG antioxidant activity and extraction yield. Optimized extraction conditions provide useful economic advantages in KRG development for functional products. |
format | Online Article Text |
id | pubmed-5005304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-50053042016-09-09 Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology Lee, Jin Woo Mo, Eun Jin Choi, Ji Eun Jo, Yang Hee Jang, Hari Jeong, Ji Yeon Jin, Qinghao Chung, Hee Nam Hwang, Bang Yeon Lee, Mi Kyeong J Ginseng Res Research Article BACKGROUND: Extraction conditions greatly affect composition, as well as biological activity. Therefore, optimization is essential for maximum efficacy. METHODS: Korean Red Ginseng (KRG) was extracted under different conditions and antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content evaluated. Optimized extraction conditions were suggested using response surface methodology for maximum antioxidant activity and extraction yield. RESULTS: Analysis of KRG extraction conditions using response surface methodology showed a good fit of experimental data as demonstrated by regression analysis. Among extraction factors, such as extraction solvent and extraction time and temperature, ethanol concentration greatly affected antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content. The optimal conditions for maximum antioxidant activity and extraction yield were an ethanol concentration of 48.8%, an extraction time 73.3 min, and an extraction temperature of 90°C. The antioxidant activity and extraction yield under optimal conditions were 43.7% and 23.2% of dried KRG, respectively. CONCLUSION: Ethanol concentration is an important extraction factor for KRG antioxidant activity and extraction yield. Optimized extraction conditions provide useful economic advantages in KRG development for functional products. Elsevier 2016-07 2015-08-20 /pmc/articles/PMC5005304/ /pubmed/27616898 http://dx.doi.org/10.1016/j.jgr.2015.08.001 Text en Copyright © 2015, The Korean Society of Ginseng, Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Lee, Jin Woo Mo, Eun Jin Choi, Ji Eun Jo, Yang Hee Jang, Hari Jeong, Ji Yeon Jin, Qinghao Chung, Hee Nam Hwang, Bang Yeon Lee, Mi Kyeong Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology |
title | Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology |
title_full | Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology |
title_fullStr | Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology |
title_full_unstemmed | Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology |
title_short | Effect of Korean Red Ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside Rg1 and phenolic content: optimization using response surface methodology |
title_sort | effect of korean red ginseng extraction conditions on antioxidant activity, extraction yield, and ginsenoside rg1 and phenolic content: optimization using response surface methodology |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005304/ https://www.ncbi.nlm.nih.gov/pubmed/27616898 http://dx.doi.org/10.1016/j.jgr.2015.08.001 |
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