Multicenter Evaluation of the Solana Group A Streptococcus Assay: Comparison with Culture

We compared group A Streptococcus (GAS) culture with a rapid helicase-dependent amplification (HDA) method using 1,082 throat swab specimens. The HDA method demonstrated 98.2% sensitivity and 97.2% specificity. GAS prevalence by culture was 20.7%, and it was 22.6% using the HDA method. In 35 min, th...

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Detalles Bibliográficos
Autores principales: Uphoff, Timothy S., Buchan, Blake W., Ledeboer, Nathan A., Granato, Paul A., Daly, Judy A., Marti, Tara N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Bacteriology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005512/
https://www.ncbi.nlm.nih.gov/pubmed/27358464
http://dx.doi.org/10.1128/JCM.01268-16
Descripción
Sumario:We compared group A Streptococcus (GAS) culture with a rapid helicase-dependent amplification (HDA) method using 1,082 throat swab specimens. The HDA method demonstrated 98.2% sensitivity and 97.2% specificity. GAS prevalence by culture was 20.7%, and it was 22.6% using the HDA method. In 35 min, the HDA method provided rapid, sensitive GAS detection, making culture confirmation unnecessary.

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