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Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric

Yellow discoloration of the skin may be caused by several etiologies, including jaundice, hypervitaminosis, drug reaction or chemical exposure. Herein we describe a 68-year-old woman with a history of breast and thyroid carcinoma, presenting with a yellow discoloration of her soles, after ingestion...

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Detalles Bibliográficos
Autores principales: Horev, Liran, Ramot, Yuval, Klapholz, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005595/
https://www.ncbi.nlm.nih.gov/pubmed/27747716
http://dx.doi.org/10.1007/s40800-015-0006-4
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author Horev, Liran
Ramot, Yuval
Klapholz, Laurent
author_facet Horev, Liran
Ramot, Yuval
Klapholz, Laurent
author_sort Horev, Liran
collection PubMed
description Yellow discoloration of the skin may be caused by several etiologies, including jaundice, hypervitaminosis, drug reaction or chemical exposure. Herein we describe a 68-year-old woman with a history of breast and thyroid carcinoma, presenting with a yellow discoloration of her soles, after ingestion of one capsule a day of turmeric root extract (Bluebonnet Turmeric Root, 500 mg, Vcap), taken for its anti-cancer properties, for 4 months. After drug cessation, the yellow hue disappeared completely. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient’s symptom and her use of the drug. Curcumin, a mixture of diferuloymethane derivatives known as curcuminoids, is a yellow pigment present in the spice turmeric. Topical application of curcumin to the human skin is joined by orange-yellow discoloration. To the best of our knowledge, yellow skin discoloration after oral intake of turmeric is not mentioned in the medical literature.
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spelling pubmed-50055952016-08-31 Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric Horev, Liran Ramot, Yuval Klapholz, Laurent Drug Saf Case Rep Case Report Yellow discoloration of the skin may be caused by several etiologies, including jaundice, hypervitaminosis, drug reaction or chemical exposure. Herein we describe a 68-year-old woman with a history of breast and thyroid carcinoma, presenting with a yellow discoloration of her soles, after ingestion of one capsule a day of turmeric root extract (Bluebonnet Turmeric Root, 500 mg, Vcap), taken for its anti-cancer properties, for 4 months. After drug cessation, the yellow hue disappeared completely. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient’s symptom and her use of the drug. Curcumin, a mixture of diferuloymethane derivatives known as curcuminoids, is a yellow pigment present in the spice turmeric. Topical application of curcumin to the human skin is joined by orange-yellow discoloration. To the best of our knowledge, yellow skin discoloration after oral intake of turmeric is not mentioned in the medical literature. Springer International Publishing 2015-03-26 /pmc/articles/PMC5005595/ /pubmed/27747716 http://dx.doi.org/10.1007/s40800-015-0006-4 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by-nc/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Case Report
Horev, Liran
Ramot, Yuval
Klapholz, Laurent
Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric
title Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric
title_full Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric
title_fullStr Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric
title_full_unstemmed Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric
title_short Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric
title_sort yellow feet in a patient with breast and thyroid carcinoma, due to oral intake of turmeric
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005595/
https://www.ncbi.nlm.nih.gov/pubmed/27747716
http://dx.doi.org/10.1007/s40800-015-0006-4
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