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Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits

BACKGROUND: In this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed. METHODS: The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 70...

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Autores principales: Bodelón, Oscar G., Clemente, Celia, Alobera, Miguel Angel, Aguado-Henche, Soledad, Escudero, María Lorenza, Alonso, María Cristina García
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005616/
https://www.ncbi.nlm.nih.gov/pubmed/27747710
http://dx.doi.org/10.1186/s40729-016-0051-5
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author Bodelón, Oscar G.
Clemente, Celia
Alobera, Miguel Angel
Aguado-Henche, Soledad
Escudero, María Lorenza
Alonso, María Cristina García
author_facet Bodelón, Oscar G.
Clemente, Celia
Alobera, Miguel Angel
Aguado-Henche, Soledad
Escudero, María Lorenza
Alonso, María Cristina García
author_sort Bodelón, Oscar G.
collection PubMed
description BACKGROUND: In this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed. METHODS: The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 700 °C for 1 h and the influence of local administration of growth hormone (GH) in osteoporotic female rabbits after 15 and 30 days of implantation have been studied. Bone response was analysed through densitometric and histomorphometric studies. Characterization of the surface was provided by scanning electron microscopy. RESULTS: The oxidation treatment promotes the formation of an oxide scale grown on the Ti6Al4V implants that alters the nanoroughness of the surface. Bone mineral density (BMD) increases from 0.347 ± 0.014 (commercial) to 0.383 ± 0.012 g cm−2 (modified), and bone-to-implant contact (BIC) goes from 48.01 ± 14.78 (commercial) to 55.37 ± 15.31 (modified) after 30 days of implantation. CONCLUSIONS: The oxidation treatment on the Ti6Al4V dental implants enhances the early bone formation at the longest periods of implantation. No significant differences in the BMD and BIC results in healthy and osteoporotic rabbits were revealed with respect to the local administration of GH in the implantation site.
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spelling pubmed-50056162016-08-31 Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits Bodelón, Oscar G. Clemente, Celia Alobera, Miguel Angel Aguado-Henche, Soledad Escudero, María Lorenza Alonso, María Cristina García Int J Implant Dent Research BACKGROUND: In this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed. METHODS: The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 700 °C for 1 h and the influence of local administration of growth hormone (GH) in osteoporotic female rabbits after 15 and 30 days of implantation have been studied. Bone response was analysed through densitometric and histomorphometric studies. Characterization of the surface was provided by scanning electron microscopy. RESULTS: The oxidation treatment promotes the formation of an oxide scale grown on the Ti6Al4V implants that alters the nanoroughness of the surface. Bone mineral density (BMD) increases from 0.347 ± 0.014 (commercial) to 0.383 ± 0.012 g cm−2 (modified), and bone-to-implant contact (BIC) goes from 48.01 ± 14.78 (commercial) to 55.37 ± 15.31 (modified) after 30 days of implantation. CONCLUSIONS: The oxidation treatment on the Ti6Al4V dental implants enhances the early bone formation at the longest periods of implantation. No significant differences in the BMD and BIC results in healthy and osteoporotic rabbits were revealed with respect to the local administration of GH in the implantation site. Springer Berlin Heidelberg 2016-07-21 /pmc/articles/PMC5005616/ /pubmed/27747710 http://dx.doi.org/10.1186/s40729-016-0051-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Bodelón, Oscar G.
Clemente, Celia
Alobera, Miguel Angel
Aguado-Henche, Soledad
Escudero, María Lorenza
Alonso, María Cristina García
Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits
title Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits
title_full Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits
title_fullStr Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits
title_full_unstemmed Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits
title_short Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits
title_sort osseointegration of ti6al4v dental implants modified by thermal oxidation in osteoporotic rabbits
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005616/
https://www.ncbi.nlm.nih.gov/pubmed/27747710
http://dx.doi.org/10.1186/s40729-016-0051-5
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