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Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits
BACKGROUND: In this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed. METHODS: The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 70...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005616/ https://www.ncbi.nlm.nih.gov/pubmed/27747710 http://dx.doi.org/10.1186/s40729-016-0051-5 |
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author | Bodelón, Oscar G. Clemente, Celia Alobera, Miguel Angel Aguado-Henche, Soledad Escudero, María Lorenza Alonso, María Cristina García |
author_facet | Bodelón, Oscar G. Clemente, Celia Alobera, Miguel Angel Aguado-Henche, Soledad Escudero, María Lorenza Alonso, María Cristina García |
author_sort | Bodelón, Oscar G. |
collection | PubMed |
description | BACKGROUND: In this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed. METHODS: The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 700 °C for 1 h and the influence of local administration of growth hormone (GH) in osteoporotic female rabbits after 15 and 30 days of implantation have been studied. Bone response was analysed through densitometric and histomorphometric studies. Characterization of the surface was provided by scanning electron microscopy. RESULTS: The oxidation treatment promotes the formation of an oxide scale grown on the Ti6Al4V implants that alters the nanoroughness of the surface. Bone mineral density (BMD) increases from 0.347 ± 0.014 (commercial) to 0.383 ± 0.012 g cm−2 (modified), and bone-to-implant contact (BIC) goes from 48.01 ± 14.78 (commercial) to 55.37 ± 15.31 (modified) after 30 days of implantation. CONCLUSIONS: The oxidation treatment on the Ti6Al4V dental implants enhances the early bone formation at the longest periods of implantation. No significant differences in the BMD and BIC results in healthy and osteoporotic rabbits were revealed with respect to the local administration of GH in the implantation site. |
format | Online Article Text |
id | pubmed-5005616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-50056162016-08-31 Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits Bodelón, Oscar G. Clemente, Celia Alobera, Miguel Angel Aguado-Henche, Soledad Escudero, María Lorenza Alonso, María Cristina García Int J Implant Dent Research BACKGROUND: In this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed. METHODS: The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 700 °C for 1 h and the influence of local administration of growth hormone (GH) in osteoporotic female rabbits after 15 and 30 days of implantation have been studied. Bone response was analysed through densitometric and histomorphometric studies. Characterization of the surface was provided by scanning electron microscopy. RESULTS: The oxidation treatment promotes the formation of an oxide scale grown on the Ti6Al4V implants that alters the nanoroughness of the surface. Bone mineral density (BMD) increases from 0.347 ± 0.014 (commercial) to 0.383 ± 0.012 g cm−2 (modified), and bone-to-implant contact (BIC) goes from 48.01 ± 14.78 (commercial) to 55.37 ± 15.31 (modified) after 30 days of implantation. CONCLUSIONS: The oxidation treatment on the Ti6Al4V dental implants enhances the early bone formation at the longest periods of implantation. No significant differences in the BMD and BIC results in healthy and osteoporotic rabbits were revealed with respect to the local administration of GH in the implantation site. Springer Berlin Heidelberg 2016-07-21 /pmc/articles/PMC5005616/ /pubmed/27747710 http://dx.doi.org/10.1186/s40729-016-0051-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Bodelón, Oscar G. Clemente, Celia Alobera, Miguel Angel Aguado-Henche, Soledad Escudero, María Lorenza Alonso, María Cristina García Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits |
title | Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits |
title_full | Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits |
title_fullStr | Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits |
title_full_unstemmed | Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits |
title_short | Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits |
title_sort | osseointegration of ti6al4v dental implants modified by thermal oxidation in osteoporotic rabbits |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005616/ https://www.ncbi.nlm.nih.gov/pubmed/27747710 http://dx.doi.org/10.1186/s40729-016-0051-5 |
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