The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma

Accumulating evidence suggests that hepatocellular carcinoma (HCC) is organized by liver cancer stem cells (LCSCs), which are a subset of cells with “stem-like” characteristics. Identification of the LCSCs is a fundamental and important problem in HCC research. LCSCs have been investigated by variou...

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Detalles Bibliográficos
Autores principales: Xiang, Yan, Yang, Ting, Pang, Bing-yao, Zhu, Ying, Liu, Yong-ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005617/
https://www.ncbi.nlm.nih.gov/pubmed/27610139
http://dx.doi.org/10.1155/2016/7614971
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author Xiang, Yan
Yang, Ting
Pang, Bing-yao
Zhu, Ying
Liu, Yong-ning
author_facet Xiang, Yan
Yang, Ting
Pang, Bing-yao
Zhu, Ying
Liu, Yong-ning
author_sort Xiang, Yan
collection PubMed
description Accumulating evidence suggests that hepatocellular carcinoma (HCC) is organized by liver cancer stem cells (LCSCs), which are a subset of cells with “stem-like” characteristics. Identification of the LCSCs is a fundamental and important problem in HCC research. LCSCs have been investigated by various stem cell biomarkers. There is still lack of consensus regarding the existence of a “global” marker for LCSCs in HCC. In this review article, we summarize the progress and prospects of putative biomarkers for LCSCs in the past decades, which is essential to develop future therapies targeting CSCs and to predict prognosis and curative effect of these therapies.
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spelling pubmed-50056172016-09-08 The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma Xiang, Yan Yang, Ting Pang, Bing-yao Zhu, Ying Liu, Yong-ning Stem Cells Int Review Article Accumulating evidence suggests that hepatocellular carcinoma (HCC) is organized by liver cancer stem cells (LCSCs), which are a subset of cells with “stem-like” characteristics. Identification of the LCSCs is a fundamental and important problem in HCC research. LCSCs have been investigated by various stem cell biomarkers. There is still lack of consensus regarding the existence of a “global” marker for LCSCs in HCC. In this review article, we summarize the progress and prospects of putative biomarkers for LCSCs in the past decades, which is essential to develop future therapies targeting CSCs and to predict prognosis and curative effect of these therapies. Hindawi Publishing Corporation 2016 2016-08-17 /pmc/articles/PMC5005617/ /pubmed/27610139 http://dx.doi.org/10.1155/2016/7614971 Text en Copyright © 2016 Yan Xiang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xiang, Yan
Yang, Ting
Pang, Bing-yao
Zhu, Ying
Liu, Yong-ning
The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma
title The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma
title_full The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma
title_fullStr The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma
title_full_unstemmed The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma
title_short The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma
title_sort progress and prospects of putative biomarkers for liver cancer stem cells in hepatocellular carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005617/
https://www.ncbi.nlm.nih.gov/pubmed/27610139
http://dx.doi.org/10.1155/2016/7614971
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