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Brain iron deposits and lifespan cognitive ability
Several studies have reported associations between brain iron deposits and cognitive status, and cardiovascular and neurodegenerative diseases in older individuals, but the mechanisms underlying these associations remain unclear. We explored the associations between regional brain iron deposits and...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005839/ https://www.ncbi.nlm.nih.gov/pubmed/26378028 http://dx.doi.org/10.1007/s11357-015-9837-2 |
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author | del C. Valdés Hernández, Maria Ritchie, Stuart Glatz, Andreas Allerhand, Mike Muñoz Maniega, Susana Gow, Alan J. Royle, Natalie A. Bastin, Mark E. Starr, John M. Deary, Ian J. Wardlaw, Joanna M. |
author_facet | del C. Valdés Hernández, Maria Ritchie, Stuart Glatz, Andreas Allerhand, Mike Muñoz Maniega, Susana Gow, Alan J. Royle, Natalie A. Bastin, Mark E. Starr, John M. Deary, Ian J. Wardlaw, Joanna M. |
author_sort | del C. Valdés Hernández, Maria |
collection | PubMed |
description | Several studies have reported associations between brain iron deposits and cognitive status, and cardiovascular and neurodegenerative diseases in older individuals, but the mechanisms underlying these associations remain unclear. We explored the associations between regional brain iron deposits and different factors of cognitive ability (fluid intelligence, speed and memory) in a large sample (n = 662) of individuals with a mean age of 73 years. Brain iron deposits in the corpus striatum were extracted automatically. Iron deposits in other parts of the brain (i.e., white matter, thalamus, brainstem and cortex), brain tissue volume and white matter hyperintensities (WMH) were assessed separately and semi-automatically. Overall, 72.8 % of the sample had iron deposits. The total volume of iron deposits had a small but significant negative association with all three cognitive ability factors in later life (mean r = −0.165), but no relation to intelligence in childhood (r = 0.043, p = 0.282). Regression models showed that these iron deposit associations were still present after control for a variety of vascular health factors, and were separable from the association of WMH with cognitive ability. Iron deposits were also associated with cognition across the lifespan, indicating that they are relevant for cognitive ability only at older ages. Iron deposits might be an indicator of small vessel disease that affects the neuronal networks underlying higher cognitive functioning. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11357-015-9837-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5005839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-50058392016-09-02 Brain iron deposits and lifespan cognitive ability del C. Valdés Hernández, Maria Ritchie, Stuart Glatz, Andreas Allerhand, Mike Muñoz Maniega, Susana Gow, Alan J. Royle, Natalie A. Bastin, Mark E. Starr, John M. Deary, Ian J. Wardlaw, Joanna M. Age (Dordr) Article Several studies have reported associations between brain iron deposits and cognitive status, and cardiovascular and neurodegenerative diseases in older individuals, but the mechanisms underlying these associations remain unclear. We explored the associations between regional brain iron deposits and different factors of cognitive ability (fluid intelligence, speed and memory) in a large sample (n = 662) of individuals with a mean age of 73 years. Brain iron deposits in the corpus striatum were extracted automatically. Iron deposits in other parts of the brain (i.e., white matter, thalamus, brainstem and cortex), brain tissue volume and white matter hyperintensities (WMH) were assessed separately and semi-automatically. Overall, 72.8 % of the sample had iron deposits. The total volume of iron deposits had a small but significant negative association with all three cognitive ability factors in later life (mean r = −0.165), but no relation to intelligence in childhood (r = 0.043, p = 0.282). Regression models showed that these iron deposit associations were still present after control for a variety of vascular health factors, and were separable from the association of WMH with cognitive ability. Iron deposits were also associated with cognition across the lifespan, indicating that they are relevant for cognitive ability only at older ages. Iron deposits might be an indicator of small vessel disease that affects the neuronal networks underlying higher cognitive functioning. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11357-015-9837-2) contains supplementary material, which is available to authorized users. Springer International Publishing 2015-09-17 2015-10 /pmc/articles/PMC5005839/ /pubmed/26378028 http://dx.doi.org/10.1007/s11357-015-9837-2 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article del C. Valdés Hernández, Maria Ritchie, Stuart Glatz, Andreas Allerhand, Mike Muñoz Maniega, Susana Gow, Alan J. Royle, Natalie A. Bastin, Mark E. Starr, John M. Deary, Ian J. Wardlaw, Joanna M. Brain iron deposits and lifespan cognitive ability |
title | Brain iron deposits and lifespan cognitive ability |
title_full | Brain iron deposits and lifespan cognitive ability |
title_fullStr | Brain iron deposits and lifespan cognitive ability |
title_full_unstemmed | Brain iron deposits and lifespan cognitive ability |
title_short | Brain iron deposits and lifespan cognitive ability |
title_sort | brain iron deposits and lifespan cognitive ability |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005839/ https://www.ncbi.nlm.nih.gov/pubmed/26378028 http://dx.doi.org/10.1007/s11357-015-9837-2 |
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