Cargando…
Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model
Cortical feedback pathways are hypothesized to distribute context-dependent signals during flexible behavior. Recent experimental work has attempted to understand the mechanisms by which cortical feedback inputs modulate their target regions. Within the mouse whisker sensorimotor system, cortical fe...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006104/ https://www.ncbi.nlm.nih.gov/pubmed/27595137 http://dx.doi.org/10.1523/ENEURO.0208-16.2016 |
_version_ | 1782451012688150528 |
---|---|
author | Zagha, Edward Murray, John D. McCormick, David A. |
author_facet | Zagha, Edward Murray, John D. McCormick, David A. |
author_sort | Zagha, Edward |
collection | PubMed |
description | Cortical feedback pathways are hypothesized to distribute context-dependent signals during flexible behavior. Recent experimental work has attempted to understand the mechanisms by which cortical feedback inputs modulate their target regions. Within the mouse whisker sensorimotor system, cortical feedback stimulation modulates spontaneous activity and sensory responsiveness, leading to enhanced sensory representations. However, the cellular mechanisms underlying these effects are currently unknown. In this study we use a simplified neural circuit model, which includes two recurrent excitatory populations and global inhibition, to simulate cortical modulation. First, we demonstrate how changes in the strengths of excitation and inhibition alter the input–output processing responses of our model. Second, we compare these responses with experimental findings from cortical feedback stimulation. Our analyses predict that enhanced inhibition underlies the changes in spontaneous and sensory evoked activity observed experimentally. More generally, these analyses provide a framework for relating cellular and synaptic properties to emergent circuit function and dynamic modulation. |
format | Online Article Text |
id | pubmed-5006104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-50061042016-09-02 Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model Zagha, Edward Murray, John D. McCormick, David A. eNeuro New Research Cortical feedback pathways are hypothesized to distribute context-dependent signals during flexible behavior. Recent experimental work has attempted to understand the mechanisms by which cortical feedback inputs modulate their target regions. Within the mouse whisker sensorimotor system, cortical feedback stimulation modulates spontaneous activity and sensory responsiveness, leading to enhanced sensory representations. However, the cellular mechanisms underlying these effects are currently unknown. In this study we use a simplified neural circuit model, which includes two recurrent excitatory populations and global inhibition, to simulate cortical modulation. First, we demonstrate how changes in the strengths of excitation and inhibition alter the input–output processing responses of our model. Second, we compare these responses with experimental findings from cortical feedback stimulation. Our analyses predict that enhanced inhibition underlies the changes in spontaneous and sensory evoked activity observed experimentally. More generally, these analyses provide a framework for relating cellular and synaptic properties to emergent circuit function and dynamic modulation. Society for Neuroscience 2016-08-31 /pmc/articles/PMC5006104/ /pubmed/27595137 http://dx.doi.org/10.1523/ENEURO.0208-16.2016 Text en Copyright © 2016 Zagha et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | New Research Zagha, Edward Murray, John D. McCormick, David A. Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model |
title | Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model
|
title_full | Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model
|
title_fullStr | Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model
|
title_full_unstemmed | Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model
|
title_short | Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model
|
title_sort | simulating cortical feedback modulation as changes in excitation and inhibition in a cortical circuit model |
topic | New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006104/ https://www.ncbi.nlm.nih.gov/pubmed/27595137 http://dx.doi.org/10.1523/ENEURO.0208-16.2016 |
work_keys_str_mv | AT zaghaedward simulatingcorticalfeedbackmodulationaschangesinexcitationandinhibitioninacorticalcircuitmodel AT murrayjohnd simulatingcorticalfeedbackmodulationaschangesinexcitationandinhibitioninacorticalcircuitmodel AT mccormickdavida simulatingcorticalfeedbackmodulationaschangesinexcitationandinhibitioninacorticalcircuitmodel |