Influence of HLA on human partnership and sexual satisfaction

The major histocompatibility complex (MHC, called HLA in humans) is an important genetic component of the immune system. Fish, birds and mammals prefer mates with different genetic MHC code compared to their own, which they determine using olfactory cues. This preference increases the chances of hig...

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Autores principales: Kromer, J., Hummel, T., Pietrowski, D., Giani, A. S., Sauter, J., Ehninger, G., Schmidt, A. H., Croy, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006172/
https://www.ncbi.nlm.nih.gov/pubmed/27578547
http://dx.doi.org/10.1038/srep32550
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author Kromer, J.
Hummel, T.
Pietrowski, D.
Giani, A. S.
Sauter, J.
Ehninger, G.
Schmidt, A. H.
Croy, I.
author_facet Kromer, J.
Hummel, T.
Pietrowski, D.
Giani, A. S.
Sauter, J.
Ehninger, G.
Schmidt, A. H.
Croy, I.
author_sort Kromer, J.
collection PubMed
description The major histocompatibility complex (MHC, called HLA in humans) is an important genetic component of the immune system. Fish, birds and mammals prefer mates with different genetic MHC code compared to their own, which they determine using olfactory cues. This preference increases the chances of high MHC variety in the offspring, leading to enhanced resilience against a variety of pathogens. Humans are also able to discriminate HLA related olfactory stimuli, however, it is debated whether this mechanism is of behavioural relevance. We show on a large sample (N = 508), with high-resolution typing of HLA class I/II, that HLA dissimilarity correlates with partnership, sexuality and enhances the desire to procreate. We conclude that HLA mediates mate behaviour in humans.
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spelling pubmed-50061722016-09-07 Influence of HLA on human partnership and sexual satisfaction Kromer, J. Hummel, T. Pietrowski, D. Giani, A. S. Sauter, J. Ehninger, G. Schmidt, A. H. Croy, I. Sci Rep Article The major histocompatibility complex (MHC, called HLA in humans) is an important genetic component of the immune system. Fish, birds and mammals prefer mates with different genetic MHC code compared to their own, which they determine using olfactory cues. This preference increases the chances of high MHC variety in the offspring, leading to enhanced resilience against a variety of pathogens. Humans are also able to discriminate HLA related olfactory stimuli, however, it is debated whether this mechanism is of behavioural relevance. We show on a large sample (N = 508), with high-resolution typing of HLA class I/II, that HLA dissimilarity correlates with partnership, sexuality and enhances the desire to procreate. We conclude that HLA mediates mate behaviour in humans. Nature Publishing Group 2016-08-31 /pmc/articles/PMC5006172/ /pubmed/27578547 http://dx.doi.org/10.1038/srep32550 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Kromer, J.
Hummel, T.
Pietrowski, D.
Giani, A. S.
Sauter, J.
Ehninger, G.
Schmidt, A. H.
Croy, I.
Influence of HLA on human partnership and sexual satisfaction
title Influence of HLA on human partnership and sexual satisfaction
title_full Influence of HLA on human partnership and sexual satisfaction
title_fullStr Influence of HLA on human partnership and sexual satisfaction
title_full_unstemmed Influence of HLA on human partnership and sexual satisfaction
title_short Influence of HLA on human partnership and sexual satisfaction
title_sort influence of hla on human partnership and sexual satisfaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006172/
https://www.ncbi.nlm.nih.gov/pubmed/27578547
http://dx.doi.org/10.1038/srep32550
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