Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models

A systems pharmacology model typically integrates pharmacokinetic, biochemical network, and systems biology concepts into a unifying approach. It typically consists of a large number of parameters and reaction species that are interlinked based upon the underlying (patho)physiology and the mechanism...

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Detalles Bibliográficos
Autores principales: Zhang, X‐Y, Trame, MN, Lesko, LJ, Schmidt, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006244/
https://www.ncbi.nlm.nih.gov/pubmed/27548289
http://dx.doi.org/10.1002/psp4.6
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author Zhang, X‐Y
Trame, MN
Lesko, LJ
Schmidt, S
author_facet Zhang, X‐Y
Trame, MN
Lesko, LJ
Schmidt, S
author_sort Zhang, X‐Y
collection PubMed
description A systems pharmacology model typically integrates pharmacokinetic, biochemical network, and systems biology concepts into a unifying approach. It typically consists of a large number of parameters and reaction species that are interlinked based upon the underlying (patho)physiology and the mechanism of drug action. The more complex these models are, the greater the challenge of reliably identifying and estimating respective model parameters. Global sensitivity analysis provides an innovative tool that can meet this challenge. CPT Pharmacometrics Syst. Pharmacol. (2015) 4, 69–79; doi:10.1002/psp4.6; published online 25 February 2015
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spelling pubmed-50062442016-09-01 Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models Zhang, X‐Y Trame, MN Lesko, LJ Schmidt, S CPT Pharmacometrics Syst Pharmacol Tutorial A systems pharmacology model typically integrates pharmacokinetic, biochemical network, and systems biology concepts into a unifying approach. It typically consists of a large number of parameters and reaction species that are interlinked based upon the underlying (patho)physiology and the mechanism of drug action. The more complex these models are, the greater the challenge of reliably identifying and estimating respective model parameters. Global sensitivity analysis provides an innovative tool that can meet this challenge. CPT Pharmacometrics Syst. Pharmacol. (2015) 4, 69–79; doi:10.1002/psp4.6; published online 25 February 2015 John Wiley and Sons Inc. 2015-02 2015-02-26 /pmc/articles/PMC5006244/ /pubmed/27548289 http://dx.doi.org/10.1002/psp4.6 Text en © 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Tutorial
Zhang, X‐Y
Trame, MN
Lesko, LJ
Schmidt, S
Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models
title Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models
title_full Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models
title_fullStr Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models
title_full_unstemmed Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models
title_short Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models
title_sort sobol sensitivity analysis: a tool to guide the development and evaluation of systems pharmacology models
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006244/
https://www.ncbi.nlm.nih.gov/pubmed/27548289
http://dx.doi.org/10.1002/psp4.6
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