The epigenome: the next substrate for engineering

We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness these changes for applications. We review the design and state of epigenome editing tools,...

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Detalles Bibliográficos
Autores principales: Park, Minhee, Keung, Albert J., Khalil, Ahmad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006378/
https://www.ncbi.nlm.nih.gov/pubmed/27582168
http://dx.doi.org/10.1186/s13059-016-1046-5
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author Park, Minhee
Keung, Albert J.
Khalil, Ahmad S.
author_facet Park, Minhee
Keung, Albert J.
Khalil, Ahmad S.
author_sort Park, Minhee
collection PubMed
description We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness these changes for applications. We review the design and state of epigenome editing tools, highlighting the unique regulatory properties afforded by these systems.
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spelling pubmed-50063782016-09-01 The epigenome: the next substrate for engineering Park, Minhee Keung, Albert J. Khalil, Ahmad S. Genome Biol Review We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness these changes for applications. We review the design and state of epigenome editing tools, highlighting the unique regulatory properties afforded by these systems. BioMed Central 2016-08-31 /pmc/articles/PMC5006378/ /pubmed/27582168 http://dx.doi.org/10.1186/s13059-016-1046-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Park, Minhee
Keung, Albert J.
Khalil, Ahmad S.
The epigenome: the next substrate for engineering
title The epigenome: the next substrate for engineering
title_full The epigenome: the next substrate for engineering
title_fullStr The epigenome: the next substrate for engineering
title_full_unstemmed The epigenome: the next substrate for engineering
title_short The epigenome: the next substrate for engineering
title_sort epigenome: the next substrate for engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006378/
https://www.ncbi.nlm.nih.gov/pubmed/27582168
http://dx.doi.org/10.1186/s13059-016-1046-5
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