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Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption
BACKGROUND: CD8 T cell-mediated blood-brain barrier (BBB) disruption is dependent on the effector molecule perforin. Human perforin has extensive single nucleotide variants (SNVs), the significance of which is not fully understood. These SNVs can result in reduced, but not ablated, perforin activity...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006384/ https://www.ncbi.nlm.nih.gov/pubmed/27576583 http://dx.doi.org/10.1186/s12974-016-0673-9 |