Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption

BACKGROUND: CD8 T cell-mediated blood-brain barrier (BBB) disruption is dependent on the effector molecule perforin. Human perforin has extensive single nucleotide variants (SNVs), the significance of which is not fully understood. These SNVs can result in reduced, but not ablated, perforin activity...

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Detalles Bibliográficos
Autores principales: Willenbring, Robin C., Jin, Fang, Hinton, David J., Hansen, Mike, Choi, Doo-Sup, Pavelko, Kevin D., Johnson, Aaron J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006384/
https://www.ncbi.nlm.nih.gov/pubmed/27576583
http://dx.doi.org/10.1186/s12974-016-0673-9

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