MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapy

BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemotherapy for breast cancer is associated with improved prognosis in aggressive tumor subtypes, including ERBB2- positive tumors. Recent adoption of pCR as a surrogate endpoint for clinical trials in early stage breast cancer in the...

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Detalles Bibliográficos
Autores principales: Calhoun, Benjamin C., Portier, Bryce, Wang, Zhen, Minca, Eugen C., Budd, G. Thomas, Lanigan, Christopher, Tubbs, Raymond R., Morrison, Larry E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006506/
https://www.ncbi.nlm.nih.gov/pubmed/27576528
http://dx.doi.org/10.1186/s12885-016-2743-x

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