High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure

Clevidipine, a dihydropyridine (DHP) analogue, lowers blood pressure (BP) by inhibiting l-type calcium channels (Ca(V)1.2; gene CACNA1C) predominantly located in vascular smooth muscle (VSM). However, clinical observations suggest that clevidipine acts by a more complex mechanism. Clevidipine more p...

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Detalles Bibliográficos
Autores principales: Dahl, Gerhard P., Conner, Gregory E., Qiu, Feng, Wang, Junjie, Spindler, Edward, Campagna, Jason A., Larsson, H. Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006577/
https://www.ncbi.nlm.nih.gov/pubmed/27349457
http://dx.doi.org/10.1016/j.ebiom.2016.06.027

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