Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer()

Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) inhibitors decreasing serum cholesterol and have shown promise in cancer prevention. In this study, we demonstrated the oncogenic role of HMGR in colorectal cancer (CRC) by disclosing increased HMGR activity in CRC patients...

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Detalles Bibliográficos
Autores principales: Wei, Tzu-Tang, Lin, Yi-Ting, Chen, Wen-Shu, Luo, Ping, Lin, Yu-Chin, Shun, Chia-Tung, Lin, Yi-Hsin, Chen, Jhih-Bin, Chen, Nai-Wei, Fang, Jim-Min, Wu, Ming-Shiang, Yang, Kai-Chien, Chang, Li-Chun, Tai, Kang-Yu, Liang, Jin-Tung, Chen, Ching-Chow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006731/
https://www.ncbi.nlm.nih.gov/pubmed/27448759
http://dx.doi.org/10.1016/j.ebiom.2016.07.019

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