Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time

The most striking characteristic of CHO cells is their adaptability, which enables efficient production of proteins as well as growth under a variety of culture conditions, but also results in genomic and phenotypic instability. To investigate the relative contribution of genomic and epigenetic modi...

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Detalles Bibliográficos
Autores principales: Feichtinger, Julia, Hernández, Inmaculada, Fischer, Christoph, Hanscho, Michael, Auer, Norbert, Hackl, Matthias, Jadhav, Vaibhav, Baumann, Martina, Krempl, Peter M., Schmidl, Christian, Farlik, Matthias, Schuster, Michael, Merkel, Angelika, Sommer, Andreas, Heath, Simon, Rico, Daniel, Bock, Christoph, Thallinger, Gerhard G., Borth, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006888/
https://www.ncbi.nlm.nih.gov/pubmed/27072894
http://dx.doi.org/10.1002/bit.25990

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