The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development

Lymphatic vasculature plays a crucial role in the immune response, enabling transport of dendritic cells (DCs) and antigens (Ags) into the lymph nodes. Unfortunately, the lymphatic system has also a negative role in the progression of cancer diseases, by facilitating the metastatic spread of many ca...

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Detalles Bibliográficos
Autores principales: Stachura, Joanna, Wachowska, Malgorzata, Kilarski, Witold W., Güç, Esra, Golab, Jakub, Muchowicz, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006909/
https://www.ncbi.nlm.nih.gov/pubmed/27622039
http://dx.doi.org/10.1080/2162402X.2016.1182278
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author Stachura, Joanna
Wachowska, Malgorzata
Kilarski, Witold W.
Güç, Esra
Golab, Jakub
Muchowicz, Angelika
author_facet Stachura, Joanna
Wachowska, Malgorzata
Kilarski, Witold W.
Güç, Esra
Golab, Jakub
Muchowicz, Angelika
author_sort Stachura, Joanna
collection PubMed
description Lymphatic vasculature plays a crucial role in the immune response, enabling transport of dendritic cells (DCs) and antigens (Ags) into the lymph nodes. Unfortunately, the lymphatic system has also a negative role in the progression of cancer diseases, by facilitating the metastatic spread of many carcinomas to the draining lymph nodes. The lymphatics can promote antitumor immune response as well as tumor tolerance. Here, we review the role of lymphatic endothelial cells (LECs) in tumor progression and immunity and mechanism of action in the newest anti-lymphatic therapies, including photodynamic therapy (PDT).
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spelling pubmed-50069092016-09-12 The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development Stachura, Joanna Wachowska, Malgorzata Kilarski, Witold W. Güç, Esra Golab, Jakub Muchowicz, Angelika Oncoimmunology Review Lymphatic vasculature plays a crucial role in the immune response, enabling transport of dendritic cells (DCs) and antigens (Ags) into the lymph nodes. Unfortunately, the lymphatic system has also a negative role in the progression of cancer diseases, by facilitating the metastatic spread of many carcinomas to the draining lymph nodes. The lymphatics can promote antitumor immune response as well as tumor tolerance. Here, we review the role of lymphatic endothelial cells (LECs) in tumor progression and immunity and mechanism of action in the newest anti-lymphatic therapies, including photodynamic therapy (PDT). Taylor & Francis 2016-05-13 /pmc/articles/PMC5006909/ /pubmed/27622039 http://dx.doi.org/10.1080/2162402X.2016.1182278 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Stachura, Joanna
Wachowska, Malgorzata
Kilarski, Witold W.
Güç, Esra
Golab, Jakub
Muchowicz, Angelika
The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development
title The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development
title_full The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development
title_fullStr The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development
title_full_unstemmed The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development
title_short The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development
title_sort dual role of tumor lymphatic vessels in dissemination of metastases and immune response development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006909/
https://www.ncbi.nlm.nih.gov/pubmed/27622039
http://dx.doi.org/10.1080/2162402X.2016.1182278
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