Cargando…

Characterization and influence of cardiac background sodium current in the atrioventricular node

Background inward sodium current (I(B,Na)) that influences cardiac pacemaking has been comparatively under-investigated. The aim of this study was to determine for the first time the properties and role of I(B,Na) in cells from the heart's secondary pacemaker, the atrioventricular node (AVN). M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Hongwei, Li, Jue, James, Andrew F., Inada, Shin, Choisy, Stéphanie C.M., Orchard, Clive H., Zhang, Henggui, Boyett, Mark R., Hancox, Jules C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007024/ https://www.ncbi.nlm.nih.gov/pubmed/27132017 http://dx.doi.org/10.1016/j.yjmcc.2016.04.014

Ejemplares similares

Acute desensitization of acetylcholine and endothelin-1 activated inward rectifier K(+) current in myocytes from the cardiac atrioventricular node
por: Choisy, Stéphanie C.M., et al.
Publicado: (2012)

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type I(C)(a), I(K)(r), I(f), and Na-Ca exchange
por: Choisy, Stéphanie C, et al.
Publicado: (2015)

Modulation by Endothelin-1 of Spontaneous Activity and Membrane Currents of Atrioventricular Node Myocytes from the Rabbit Heart
por: Choisy, Stéphanie C., et al.
Publicado: (2012)

Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca(2+) ATPase
por: Cheng, Hongwei, et al.
Publicado: (2011)

The Functional Role of Hyperpolarization Activated Current (I(f)) on Cardiac Pacemaking in Human vs. in the Rabbit Sinoatrial Node: A Simulation and Theoretical Study
por: Bai, Xiangyun, et al.
Publicado: (2021)

Three-Dimensional Computer Model of the Right Atrium Including the Sinoatrial and Atrioventricular Nodes Predicts Classical Nodal Behaviours
por: Li, Jue, et al.
Publicado: (2014)

Connexins and the atrioventricular node
por: Temple, Ian P., et al.
Publicado: (2013)

Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart
por: Alghamdi, Aaazh M., et al.
Publicado: (2020)

Modeling the Chronotropic Effect of Isoprenaline on Rabbit Sinoatrial Node
por: Zhang, Henggui, et al.
Publicado: (2012)

Multiple ion channel block by the cation channel inhibitor SKF‐96365 in myocytes from the rabbit atrioventricular node
por: Cheng, Hongwei, et al.
Publicado: (2016)

β-Adrenoceptor/PKA-stimulation, Na(+)–Ca(2+) exchange and PKA-activated Cl(−) currents in rabbit cardiomyocytes: A conundrum
por: Barman, Palash, et al.
Publicado: (2011)

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study
por: Alghamdi, Azzah M., et al.
Publicado: (2020)

Atrial-ventricular differences in rabbit cardiac voltage-gated Na(+) currents: Basis for atrial-selective block by ranolazine
por: Caves, Rachel E., et al.
Publicado: (2017)

Inhibition of a TREK-like K(+) channel current by noradrenaline requires both β(1)- and β(2)-adrenoceptors in rat atrial myocytes
por: Bond, Richard C., et al.
Publicado: (2014)

Acidosis slows electrical conduction through the atrio-ventricular node
por: Nisbet, Ashley M., et al.
Publicado: (2014)

Ion currents, action potentials, and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes
por: Bond, Richard C., et al.
Publicado: (2020)

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia—A simulation study
por: Wang, Wei, et al.
Publicado: (2018)

Cardiac hemangioma in the atrioventricular node localization
por: Batko, Jakub, et al.
Publicado: (2023)

Delayed Ventricular Repolarization and Sodium Channel Current Modification in a Mouse Model of Rett Syndrome
por: Cheng, Hongwei, et al.
Publicado: (2022)

Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells
por: Congreve, Samitha Dilini, et al.
Publicado: (2023)

Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria
por: Colman, Michael A, et al.
Publicado: (2013)

Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models
por: Alrabghi, Ghadah, et al.
Publicado: (2023)

Inhibition of voltage-gated Na(+) currents by eleclazine in rat atrial and ventricular myocytes
por: Caves, Rachel E., et al.
Publicado: (2020)

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling
por: Adeniran, Ismail, et al.
Publicado: (2013)

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome
por: Whittaker, Dominic G., et al.
Publicado: (2019)

Atrioventricular node dysfunction in pressure overload-induced heart failure—Involvement of the immune system and transcriptomic remodelling
por: Wilson, Claire, et al.
Publicado: (2023)

In silico investigation of pro-arrhythmic effects of azithromycin on the human ventricle
por: Liu, Yizhou, et al.
Publicado: (2021)

Pro-Arrhythmic Effects of Discontinuous Conduction at the Purkinje Fiber-Ventricle Junction Arising From Heart Failure-Induced Ionic Remodeling – Insights From Computational Modelling
por: Jian, Kun, et al.
Publicado: (2022)

Importance of Gradients in Membrane Properties and Electrical Coupling in Sinoatrial Node Pacing
por: Inada, Shin, et al.
Publicado: (2014)

Identification through action potential clamp of proarrhythmic consequences of the short QT syndrome T618I hERG ‘hotspot’ mutation
por: Du, Chunyun, et al.
Publicado: (2022)

Differential responses of rabbit ventricular and atrial transient outward current (I(to)) to the I(to) modulator NS5806
por: Cheng, Hongwei, et al.
Publicado: (2017)

Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring
por: Logantha, Sunil Jit R. J., et al.
Publicado: (2019)

Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition
por: Du, Chunyun, et al.
Publicado: (2013)

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats
por: Choisy, Stéphanie C., et al.
Publicado: (2015)

A Sluggish Atrioventricular Node
por: Dasari, Tarun W, et al.
Publicado: (2010)

Cystic tumor of the atrioventricular node
por: Giuliano, Katherine, et al.
Publicado: (2020)

Inferior Extensions of the Atrioventricular Node
por: Anderson, Robert H, et al.
Publicado: (2021)

Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an electromechanically detailed biophysical modeling study
por: Adeniran, Ismail, et al.
Publicado: (2015)

Reciprocal interaction between I(K1) and I(f) in biological pacemakers: A simulation study
por: Li, Yacong, et al.
Publicado: (2021)

Cardioneuroablation: Don’t forget atrioventricular node innervation
por: Pachon-M, Jose Carlos, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_p53cvri2l0dopjhbo3vmfmpdh4