MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence

The tumor suppressor proteins p15(INK4B), p16(INK4A), and p14(ARF), encoded by the INK4AB/ARF locus, are crucial regulators of cellular senescence. The locus is epigenetically silenced by the repressive Polycomb complexes in growing cells but is activated in response to oncogenic stress. Here we sho...

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Detalles Bibliográficos
Autores principales: Culerrier, Raphaël, Carraz, Maëlle, Mann, Carl, Djabali, Malek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007092/
https://www.ncbi.nlm.nih.gov/pubmed/27385346
http://dx.doi.org/10.1091/mbc.E15-11-0772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007092/
https://www.ncbi.nlm.nih.gov/pubmed/27385346
http://dx.doi.org/10.1091/mbc.E15-11-0772

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