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Evolutionary analyses of mitochondrial carrier family of dictyostelids

The transportation of solutes across the inner membrane of the mitochondria is catalyzed by a nuclear-coded family of transport proteins called mitochondrial carriers (MCs). Sequences from dictyostelid genome projects have facilitated analysis of the evolution of the dictyostelid mitochondrial carri...

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Autores principales: Gong, Ming, Zhu, Qiuming, Tan, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007236/
https://www.ncbi.nlm.nih.gov/pubmed/27652040
http://dx.doi.org/10.1186/s40064-016-3146-9
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author Gong, Ming
Zhu, Qiuming
Tan, Qi
author_facet Gong, Ming
Zhu, Qiuming
Tan, Qi
author_sort Gong, Ming
collection PubMed
description The transportation of solutes across the inner membrane of the mitochondria is catalyzed by a nuclear-coded family of transport proteins called mitochondrial carriers (MCs). Sequences from dictyostelid genome projects have facilitated analysis of the evolution of the dictyostelid mitochondrial carrier family (MCF). The average evolutionary distances between various regions in the MCF shows that the transmembrane region (TR) and conical pit region (CPR) are the only two conserved structural regions. A phylogenetic tree built using the concatenated orthologous TR and CPR sequences of 7 MCs showed that dictyostelids are similar to metazoans in this way. A close evolutionary relationship was observed between dictyostelids and metazoans in 4 MCs known to be related to ADP/ATP transport (MAA). This was further evidenced by the fact that dictyostelids have undergone gene expansion similar to that of metazoans during the evolution of MAA. Sequence logo analysis of CPR in MAA showed that dictyostelids have motifs similar to those of Metazoa. Combined with the conserved substrate binding site of 7 MCs in eukaryotes, it is postulated that dictyostelids are closely related to Metazoa with respect to the evolution of MAA. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40064-016-3146-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-50072362016-09-20 Evolutionary analyses of mitochondrial carrier family of dictyostelids Gong, Ming Zhu, Qiuming Tan, Qi Springerplus Research The transportation of solutes across the inner membrane of the mitochondria is catalyzed by a nuclear-coded family of transport proteins called mitochondrial carriers (MCs). Sequences from dictyostelid genome projects have facilitated analysis of the evolution of the dictyostelid mitochondrial carrier family (MCF). The average evolutionary distances between various regions in the MCF shows that the transmembrane region (TR) and conical pit region (CPR) are the only two conserved structural regions. A phylogenetic tree built using the concatenated orthologous TR and CPR sequences of 7 MCs showed that dictyostelids are similar to metazoans in this way. A close evolutionary relationship was observed between dictyostelids and metazoans in 4 MCs known to be related to ADP/ATP transport (MAA). This was further evidenced by the fact that dictyostelids have undergone gene expansion similar to that of metazoans during the evolution of MAA. Sequence logo analysis of CPR in MAA showed that dictyostelids have motifs similar to those of Metazoa. Combined with the conserved substrate binding site of 7 MCs in eukaryotes, it is postulated that dictyostelids are closely related to Metazoa with respect to the evolution of MAA. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40064-016-3146-9) contains supplementary material, which is available to authorized users. Springer International Publishing 2016-08-31 /pmc/articles/PMC5007236/ /pubmed/27652040 http://dx.doi.org/10.1186/s40064-016-3146-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Gong, Ming
Zhu, Qiuming
Tan, Qi
Evolutionary analyses of mitochondrial carrier family of dictyostelids
title Evolutionary analyses of mitochondrial carrier family of dictyostelids
title_full Evolutionary analyses of mitochondrial carrier family of dictyostelids
title_fullStr Evolutionary analyses of mitochondrial carrier family of dictyostelids
title_full_unstemmed Evolutionary analyses of mitochondrial carrier family of dictyostelids
title_short Evolutionary analyses of mitochondrial carrier family of dictyostelids
title_sort evolutionary analyses of mitochondrial carrier family of dictyostelids
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007236/
https://www.ncbi.nlm.nih.gov/pubmed/27652040
http://dx.doi.org/10.1186/s40064-016-3146-9
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