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Three atypical lethal cases associated with acute Zika virus infection in Suriname

Acute Zika virus infection usually presents with a self-limiting triad of fever, rash and arthritis. There is limited information on severe or lethal cases. We report three cases of lethal acute Zika infection, confirmed with polymerase chain reaction, in adult patients with some co-morbidities. The...

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Autores principales: Zonneveld, Rens, Roosblad, Jimmy, Staveren, Jan Willem van, Wilschut, Jan C., Vreden, Stephen G.S., Codrington, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007293/
https://www.ncbi.nlm.nih.gov/pubmed/27630820
http://dx.doi.org/10.1016/j.idcr.2016.07.009
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author Zonneveld, Rens
Roosblad, Jimmy
Staveren, Jan Willem van
Wilschut, Jan C.
Vreden, Stephen G.S.
Codrington, John
author_facet Zonneveld, Rens
Roosblad, Jimmy
Staveren, Jan Willem van
Wilschut, Jan C.
Vreden, Stephen G.S.
Codrington, John
author_sort Zonneveld, Rens
collection PubMed
description Acute Zika virus infection usually presents with a self-limiting triad of fever, rash and arthritis. There is limited information on severe or lethal cases. We report three cases of lethal acute Zika infection, confirmed with polymerase chain reaction, in adult patients with some co-morbidities. The patients showed rapid clinical deterioration with hemorrhagic and septic shock, and exaggerated acute and innate inflammatory responses with pronounced coagulopathy, and died soon after admission to the hospital. It remains unclear whether the fatal outcomes were due to acute Zika virus infection alone or to the combination with exacerbated underlying prior disease or co-infection. Nonetheless, the severity of these cases implies that increased awareness for atypical presentations of Zika virus infection, and careful clinical assessment of patients with symptoms of Zika, is warranted during current and future outbreaks.
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spelling pubmed-50072932016-09-14 Three atypical lethal cases associated with acute Zika virus infection in Suriname Zonneveld, Rens Roosblad, Jimmy Staveren, Jan Willem van Wilschut, Jan C. Vreden, Stephen G.S. Codrington, John IDCases Case Report Acute Zika virus infection usually presents with a self-limiting triad of fever, rash and arthritis. There is limited information on severe or lethal cases. We report three cases of lethal acute Zika infection, confirmed with polymerase chain reaction, in adult patients with some co-morbidities. The patients showed rapid clinical deterioration with hemorrhagic and septic shock, and exaggerated acute and innate inflammatory responses with pronounced coagulopathy, and died soon after admission to the hospital. It remains unclear whether the fatal outcomes were due to acute Zika virus infection alone or to the combination with exacerbated underlying prior disease or co-infection. Nonetheless, the severity of these cases implies that increased awareness for atypical presentations of Zika virus infection, and careful clinical assessment of patients with symptoms of Zika, is warranted during current and future outbreaks. Elsevier 2016-07-22 /pmc/articles/PMC5007293/ /pubmed/27630820 http://dx.doi.org/10.1016/j.idcr.2016.07.009 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Zonneveld, Rens
Roosblad, Jimmy
Staveren, Jan Willem van
Wilschut, Jan C.
Vreden, Stephen G.S.
Codrington, John
Three atypical lethal cases associated with acute Zika virus infection in Suriname
title Three atypical lethal cases associated with acute Zika virus infection in Suriname
title_full Three atypical lethal cases associated with acute Zika virus infection in Suriname
title_fullStr Three atypical lethal cases associated with acute Zika virus infection in Suriname
title_full_unstemmed Three atypical lethal cases associated with acute Zika virus infection in Suriname
title_short Three atypical lethal cases associated with acute Zika virus infection in Suriname
title_sort three atypical lethal cases associated with acute zika virus infection in suriname
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007293/
https://www.ncbi.nlm.nih.gov/pubmed/27630820
http://dx.doi.org/10.1016/j.idcr.2016.07.009
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