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Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer
A 76-year-old female presented to our hospital with a 2 cm firm, nontender, protuberant umbilical nodule. She received treatment with antibiotics for suspected granuloma, with no improvement after two months. High levels of CA125 as well as an ovarian cyst and intrathoracic and intra-abdominal lesio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007344/ https://www.ncbi.nlm.nih.gov/pubmed/27635270 http://dx.doi.org/10.1155/2016/1087513 |
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author | Calongos, Giannina Ogino, Mai Kinuta, Takatoshi Hori, Masateru Mori, Tatsuo |
author_facet | Calongos, Giannina Ogino, Mai Kinuta, Takatoshi Hori, Masateru Mori, Tatsuo |
author_sort | Calongos, Giannina |
collection | PubMed |
description | A 76-year-old female presented to our hospital with a 2 cm firm, nontender, protuberant umbilical nodule. She received treatment with antibiotics for suspected granuloma, with no improvement after two months. High levels of CA125 as well as an ovarian cyst and intrathoracic and intra-abdominal lesions on imaging studies made us suspect an ovarian cancer with a Sister Mary Joseph nodule (SMJN) and other metastases. A bilateral salpingo-oophorectomy and umbilical and omentum tumor resections were performed and a metastatic ovarian serous adenocarcinoma was diagnosed by histopathology. After surgery, the patient received chemotherapy with paclitaxel, carboplatin, and bevacizumab; however paclitaxel allergy was observed. As a result, chemotherapy continued with carboplatin and bevacizumab every three weeks for a total of 6 courses. Currently, she is still undergoing treatment with bevacizumab and CA125 levels have been progressively decreasing. SMJN is a rare umbilical metastasis which needs to be considered as a differential diagnosis in the presence of an umbilical tumor for prompt treatment initiation. |
format | Online Article Text |
id | pubmed-5007344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-50073442016-09-15 Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer Calongos, Giannina Ogino, Mai Kinuta, Takatoshi Hori, Masateru Mori, Tatsuo Case Rep Obstet Gynecol Case Report A 76-year-old female presented to our hospital with a 2 cm firm, nontender, protuberant umbilical nodule. She received treatment with antibiotics for suspected granuloma, with no improvement after two months. High levels of CA125 as well as an ovarian cyst and intrathoracic and intra-abdominal lesions on imaging studies made us suspect an ovarian cancer with a Sister Mary Joseph nodule (SMJN) and other metastases. A bilateral salpingo-oophorectomy and umbilical and omentum tumor resections were performed and a metastatic ovarian serous adenocarcinoma was diagnosed by histopathology. After surgery, the patient received chemotherapy with paclitaxel, carboplatin, and bevacizumab; however paclitaxel allergy was observed. As a result, chemotherapy continued with carboplatin and bevacizumab every three weeks for a total of 6 courses. Currently, she is still undergoing treatment with bevacizumab and CA125 levels have been progressively decreasing. SMJN is a rare umbilical metastasis which needs to be considered as a differential diagnosis in the presence of an umbilical tumor for prompt treatment initiation. Hindawi Publishing Corporation 2016 2016-08-18 /pmc/articles/PMC5007344/ /pubmed/27635270 http://dx.doi.org/10.1155/2016/1087513 Text en Copyright © 2016 Giannina Calongos et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Calongos, Giannina Ogino, Mai Kinuta, Takatoshi Hori, Masateru Mori, Tatsuo Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer |
title | Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer |
title_full | Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer |
title_fullStr | Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer |
title_full_unstemmed | Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer |
title_short | Sister Mary Joseph Nodule as a First Manifestation of a Metastatic Ovarian Cancer |
title_sort | sister mary joseph nodule as a first manifestation of a metastatic ovarian cancer |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007344/ https://www.ncbi.nlm.nih.gov/pubmed/27635270 http://dx.doi.org/10.1155/2016/1087513 |
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